Journal of Endocrinological Investigation

, Volume 10, Issue 4, pp 413–416 | Cite as

Effect of exogenously administered estrogens on luteinizing hormone release in a complete testicular feminization syndrome patient with very low testosterone levels, before and after gonadectomy

  • M. Marcelli
  • I. Nicoletti
  • M. A. Sansone
  • G. P. Reboldi
  • G. Angeletti
  • F. Santeusanio
  • P. Brunetti
Case Report


The response of LH to exogenously administered estrogens was evaluated in a 63-year-old patient affected by complete testicular feminization syndrome (CTFS) with very low testosterone (T) levels, before and after gonadectomy. Prior to gonadectomy a durative fall in gonadotropin levels was observed after estrogen administration, without observing of an estrogenic positive feed-back (EPF) from LH. After gonadectomy, following an initial decrement in both gonadotropins, the characteristic. LH peak was seen, 48 h after E2B (Estradiol Benzoate) administration. This observation, together with the very low T levels that we found in this patient, prompted us to construe that absence of EPF in males is not due, as previously believed, to a direct inhibitory action of T or E2, deriving from T aromatization, on the hypothalamus, but by a still unknown gonadal factor. The hypothesis that this factor has a tubular origin is formulated and discussed.


Gonadotropins follicle stimulating hormone luteinizing hormone testicular feminization syndrome estrogenic positive feed-back 


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Copyright information

© Italian Society of Endocrinology (SIE) 1987

Authors and Affiliations

  • M. Marcelli
    • 1
  • I. Nicoletti
    • 2
  • M. A. Sansone
    • 1
  • G. P. Reboldi
    • 1
  • G. Angeletti
    • 1
  • F. Santeusanio
    • 1
  • P. Brunetti
    • 1
  1. 1.Istituto di Patologia Speciale MedicaUniversity of PerugiaPerugiaItaly
  2. 2.Istituto di Clinica Medica IUniversity of PerugiaPerugiaItaly

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