Reduction of glycogen stores in a rat model of chronic hyperinsulinism
- 5 Downloads
To assess a suitable model for the study of the mechanisms of development of insulin resistance in vivo, liver and muscle glycogen levels (as a metabolic index of tissue insulin sensitivity) were investigated in rats with functioning islet cell adenomas induced by streptozotocin and nicotinamide. These rats have basal moderate hyperinsulinemia and hypoglycemia and show a remarkable increase in insulin secretion after glucose administration. Plasma glucagon concentrations are normal. Nevertheless, in tumor-bearing rats, a reduction of tissue glycogen stores occurs, related to plasma glucose concentrations, and liver glycogen fails to increase even after a glucose load. The lack of excess fat in tumor-bearing rats also suggests a certain insulin insensitivity of the adipose tissue and distinguishes this model of chronic hyperinsulinism from other reported models, such as genetically obese animals.
Key-wordsHyperinsulinism islet cell tumor rat glycogen insulin resistance
Unable to display preview. Download preview PDF.
- 2.Bergamini E., Masiello P., Pellegrino C. Aspetti biochimici di muscoli ormono-dipendenti. Riv. Istoch. Norm. Pat. 19: 72, 1975.Google Scholar
- 3.Hassid W.Z., Abraham S. Chemical procedures for analysis of polysaccharides. In: Colowick S.P., Kaplan N.O. (Eds.), Methods in Enzy. mology. Academic Press, New York, 1957, vol. 3, p. 34.Google Scholar