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Reduction of glycogen stores in a rat model of chronic hyperinsulinism

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Abstract

To assess a suitable model for the study of the mechanisms of development of insulin resistance in vivo, liver and muscle glycogen levels (as a metabolic index of tissue insulin sensitivity) were investigated in rats with functioning islet cell adenomas induced by streptozotocin and nicotinamide. These rats have basal moderate hyperinsulinemia and hypoglycemia and show a remarkable increase in insulin secretion after glucose administration. Plasma glucagon concentrations are normal. Nevertheless, in tumor-bearing rats, a reduction of tissue glycogen stores occurs, related to plasma glucose concentrations, and liver glycogen fails to increase even after a glucose load. The lack of excess fat in tumor-bearing rats also suggests a certain insulin insensitivity of the adipose tissue and distinguishes this model of chronic hyperinsulinism from other reported models, such as genetically obese animals.

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Authors and Affiliations

  1. Istituto di Patologia Generale, Scuola Medica, University of Pisa, Via Roma 55, 56100, Pisa, Italy

    P. Masiello & E. Bergamini

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  1. P. Masiello
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  2. E. Bergamini
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Masiello, P., Bergamini, E. Reduction of glycogen stores in a rat model of chronic hyperinsulinism. J Endocrinol Invest 10, 325–327 (1987). https://doi.org/10.1007/BF03348140

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  • DOI: https://doi.org/10.1007/BF03348140

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