Journal of Endocrinological Investigation

, Volume 10, Issue 3, pp 237–239 | Cite as

The effects of reverse sequential anti-androgen therapy (cyproterone acetate and ethinyl estradiol) on hematological parameters

  • J. H. Parr
  • M. Seed
  • I. Godsland
  • V. Wynn


Hematological parameters were studied in female patients receiving reverse-sequential anti-androgen therapy for hirsutism and acne. A significant fall in hemoglobin, total red cell count and packed cell volume occurred after 3-month treatment in 30 patients during the 10-day cyproterone acetate and ethinyl estradiol phase; this change was sustained in 14 patients studied to 12 months. A fall in hemoglobin and packed cell volume alone occurred after 3 months in 31 patients in the ethinyl estradiol phase. Reverse-sequential therapy may influence hemopoesis by its anti-androgenic action on erythropoiesis, although we found no relationship between changes in hematological parameters and total testosterone levels.


Cyproterone acetate ethinyl estradiol testosterone hematology 


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Copyright information

© Italian Society of Endocrinology (SIE) 1987

Authors and Affiliations

  • J. H. Parr
    • 1
  • M. Seed
    • 1
  • I. Godsland
    • 1
  • V. Wynn
    • 1
  1. 1.Alexander Simpson Laboratory for Metabolic ResearchSt. Mary’s Hospital Medical SchoolLondon W2England

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