Abstract
A role of environmental factors for the development of Medullary Carcinoma of the Thyroid (MTC) has been shown for animals, but has only been speculated for humans. In the present study we analyzed our registry of 58 sporadic MTCs for the place of origin and place of residence and compared these with 408 other thyroid carcinomas of different histology who are attending the same Endocrine Clinics in the Athens area. Clustering of sporadic MTCs was observed in the Ionian islands, where an increased incidence of familial cases has previously been observed. Patients with sporadic MTCs originated more frequently from rural areas (p=0.0006), where the main occupation is agriculture. No important differences were observed concerning the place of residence. We speculate that exposure to sunshine, which is greater in rural areas, may be one factor which, through vitamin D, could be involved in the development of C-cell tumors in predisposed individuals.
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Williams E.D. Medullary carcinoma of the thyroid. In: DeGroot L.J. (Ed.), Endocrinology, ed. 2. W.B. Saunders, Philadelphia, 1989, vol. 2, p. 1132.
Bergholm U., Adami H.-O., Bergstrom R., Johansson H., Lundell G., Telenius-Berg M., Akerstrom G. Clinical characteristics in sporadic and familial medullary carcinoma of the thyroid; a nationwide study of 249 patients in Sweden from 1959 through 1981. Cancer 63: 1196, 1989.
Miller M.M., Burton D., Deftos L.J. The effect of dietary induced obesity on thyroidal calcitonin and plasma calcitonin, calcium and phosphorus in rats. Program of the 7th Annual Meeting of the American Society for Bone and Mineral Research, Washington, DC, 1985, p. 152 (Abstract).
Thurston V., Williams E.D. Experimental induction of C-cell tumours in thyroid by increased dietary content of vitamin D. Acta Endocrinol. (Copenh.) 100: 41, 1982.
Boorman, G.A., Van Noord M.J., Hollander C.F. Naturally occurring medullary thyroid carcinoma in the rat. Arch. Pathol. 94: 35, 1972.
Saad M.F., Ordinez N.G., Rashid R.K., Guido J.J., Stratton Hill C., Hickey R.C., Samaan N.A. Medullary carcinoma of the thyroid: A study of the clinical features and prognostic factors in 161 patients. Medicine 63: 319, 1984.
Langsteger W., Koltringer P., Wolf G., Dominik K., Buchinger W., Binter G., Lax S., Eber O. The impact of geographical, clinical, dietary and radiation induced features in epidemiology of thyroid cancer Eur. J. Cancer 29: 1547, 1993.
Williams E.D., Doniach L., Bjamason O., Michie W. Thyroid cancer in an iodide rich area: a histopathological study. Cancer 39: 215, 1977.
Franssila K., Saxen E., Bjamason T.O., Tulinius H., Normann T., Ringertz N. Incidence of different morphological types of thyroid cancer in the Nordic countries. Acta Pathol. Microbiol. Scand. 89: 49, 1981.
Dean A.G., Dean J.A., Burton A.H., Dicker R.C. Epi Info, Version 5: a word processing, database, and statistics program for epidemiology on microcomputers. USD Incorporated, Stone Mountain, Georgia, 1990.
Freake H.C., Maclntyre I. Specific binding of 1,25-dihydroxycholecalciferol in human medullary thyroid carcinoma. Biochem. J. 206: 181, 1982.
Williams E.D. Medullary carcinoma of the thyroid. In: Polak J.M., Bloom S.R. (Eds.), Endocrine Tumours. Churchill Livingstone, 1985, p. 229.
Norman T. Medullary thyroid carcinoma in Norway: epidemiological and genetic data. Acta Path. Microbiol. Scand. 85: 775, 1977.
Nelkin B.D., deBustros A., Mabry M., Baylin S.B. The molecular biology of medullary thyroid carcinoma; a model for cancer development and progression. JAMA 261: 3130, 1989.
Mulligan L.M., Kwok J.B., Healey C.S., Elsdon M.J., Eng C., Gardner E., Love D.R., Mole S.E., Moore J.K., Papi L., Ponder M.A., Telenius H., Tunnacliffe A., Ponder B.A.J. Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A. Nature, 363: 458, 1993.
Eng C., Smith D.P., Mulligan L.M., Nagai M.A., Healey C.S., Ponder M.A., Gardner E., Scheumann G.F.W., Jackson C.E., Tunnacliffe A., Ponder B.A.J. Point mutation within the tyrosine kinase domain of the RET proto-oncogene in multiple endocrine neoplasia type 2B and related sporadic tumours. Hum. Mol. Genet. 3: 237, 1994.
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Alevizaki, M., Papapetrou, P., Georgouli, P. et al. Increased incidence of medullary carcinoma of the thyroid in rural regions in Greece. J Endocrinol Invest 18, 220–223 (1995). https://doi.org/10.1007/BF03347805
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DOI: https://doi.org/10.1007/BF03347805