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Expression of adhesion molecule ICAM-1 (CD54) in thyroid papillary adenocarcinoma

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Abstract

The expression of adhesion molecules in thyroid specimens from 10 cases of papillary adenocarcinoma, 5 cases of follicular adenoma and 3 normal thyroid specimens was examined by an immunohistochemical method. Thyroid epithelial cells from all cases of papillary adenocarcinoma expressed the intercellular adhesion molecule 1 (ICAM-1, CD54). The ICAM-1-positive staining in these was detected predominantly on the apical site of malignant thyroid epithelial cells. However, no ICAM-1 expression was detected on thyrocytes of adenoma, and normal thyroid tissues. Furthermore, thyroid epithelial cells in patients with thyroid tumor and normal thyroid tissue did not react with anti-LFA-1, anti-VLA-4, anti-VCAM-1 and anti-ELAM-1 monoclonal antibodies. It is speculated that ICAM-1 expression in thyroid papillary adenocarcinoma may have a functional significance.

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Authors and Affiliations

  1. First Department of Internal medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki City, Nagasaki 852, Japan

    M. Nakashima M.D., K. Eguchi, I. Yamashita, M. Sakai, H. Ida, Y. Kawabe & S. Nagataki

  2. Ito Hospital, Tokyo, Japan

    N. Ishikawa & K. Ito

Authors
  1. M. Nakashima M.D.
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  2. K. Eguchi
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  3. N. Ishikawa
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  4. I. Yamashita
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  5. M. Sakai
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  6. H. Ida
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  7. Y. Kawabe
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  8. K. Ito
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  9. S. Nagataki
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Nakashima, M., Eguchi, K., Ishikawa, N. et al. Expression of adhesion molecule ICAM-1 (CD54) in thyroid papillary adenocarcinoma. J Endocrinol Invest 17, 843–848 (1994). https://doi.org/10.1007/BF03347789

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  • DOI: https://doi.org/10.1007/BF03347789

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