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Journal of Endocrinological Investigation

, Volume 17, Issue 11, pp 843–848 | Cite as

Expression of adhesion molecule ICAM-1 (CD54) in thyroid papillary adenocarcinoma

  • M. Nakashima
  • K. Eguchi
  • N. Ishikawa
  • I. Yamashita
  • M. Sakai
  • H. Ida
  • Y. Kawabe
  • K. Ito
  • S. Nagataki
Article

Abstract

The expression of adhesion molecules in thyroid specimens from 10 cases of papillary adenocarcinoma, 5 cases of follicular adenoma and 3 normal thyroid specimens was examined by an immunohistochemical method. Thyroid epithelial cells from all cases of papillary adenocarcinoma expressed the intercellular adhesion molecule 1 (ICAM-1, CD54). The ICAM-1-positive staining in these was detected predominantly on the apical site of malignant thyroid epithelial cells. However, no ICAM-1 expression was detected on thyrocytes of adenoma, and normal thyroid tissues. Furthermore, thyroid epithelial cells in patients with thyroid tumor and normal thyroid tissue did not react with anti-LFA-1, anti-VLA-4, anti-VCAM-1 and anti-ELAM-1 monoclonal antibodies. It is speculated that ICAM-1 expression in thyroid papillary adenocarcinoma may have a functional significance.

Key-words

Adhesion molecule ICAM-1 thyroid cancer 

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Copyright information

© Italian Society of Endocrinology (SIE) 1994

Authors and Affiliations

  • M. Nakashima
    • 1
  • K. Eguchi
    • 1
  • N. Ishikawa
    • 2
  • I. Yamashita
    • 1
  • M. Sakai
    • 1
  • H. Ida
    • 1
  • Y. Kawabe
    • 1
  • K. Ito
    • 2
  • S. Nagataki
    • 1
  1. 1.First Department of Internal medicineNagasaki University School of MedicineNagasaki City, Nagasaki 852Japan
  2. 2.Ito HospitalTokyoJapan

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