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Journal of Endocrinological Investigation

, Volume 16, Issue 2, pp 133–137 | Cite as

Oxandrolone in constitutional delay of growth: Analisys of the growth patterns up to final stature

  • Francesca Bassi
  • A. S. Neri
  • R. G. Gheri
  • D. Cheli
  • M. Serio
Article

Abstract

In order to evaluate the effects of low-dosage, 6–12 months course of oxandrolone treatment in constitutional delay of growth, we compared the growth responses on treatment, the pattern of sexual development and pubertal growth events, up to final stature of 11 prepubertal boys, aged 10.6–14.1 yr, with those of 11 prepubertal, age-matched untreated controls. Treatment caused a significant increase of height velocity, from 4 to 9 cm/yr, and a significant acceleration of bone maturation, without affecting the timing of onset of puberty, the progression of sexual development or the onset of pubertal growth spurt. On the other hand, oxandrolone induced an earlier skeletal growth arrest but did not affect the expected final height. Treated boys showed an adult stature not significantly different from that of control subjects. Our data suggest that 6 months-1 year, low dosage oxandrolone treatment in constitutionally delayed growth has no significant effect on the pattern of pubertal growth, nor on the rate of sexual maturation or on final height.

Key-words

Constitutional delay of growth oxandrolone growth velocity pubertal development final stature 

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Copyright information

© Italian Society of Endocrinology (SIE) 1993

Authors and Affiliations

  • Francesca Bassi
    • 1
  • A. S. Neri
    • 2
  • R. G. Gheri
    • 1
  • D. Cheli
    • 3
  • M. Serio
    • 1
  1. 1.Dipartimento di Fisiopatologia ClinicaUniversità di FirenzeFirenzeItaly
  2. 2.Dipartimento di PediatriaUniversità di FirenzeFirenzeItaly
  3. 3.Divisione di RadiologiaUSL 10/DFirenzeItaly

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