Abstract
In order to evaluate the effects of low-dosage, 6–12 months course of oxandrolone treatment in constitutional delay of growth, we compared the growth responses on treatment, the pattern of sexual development and pubertal growth events, up to final stature of 11 prepubertal boys, aged 10.6–14.1 yr, with those of 11 prepubertal, age-matched untreated controls. Treatment caused a significant increase of height velocity, from 4 to 9 cm/yr, and a significant acceleration of bone maturation, without affecting the timing of onset of puberty, the progression of sexual development or the onset of pubertal growth spurt. On the other hand, oxandrolone induced an earlier skeletal growth arrest but did not affect the expected final height. Treated boys showed an adult stature not significantly different from that of control subjects. Our data suggest that 6 months-1 year, low dosage oxandrolone treatment in constitutionally delayed growth has no significant effect on the pattern of pubertal growth, nor on the rate of sexual maturation or on final height.
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Kelley V.C., Ruvalcaba R.H.A. Use of anabolic agents in treatment of short children. In: Sovage M.O., Randall R.A., (Eds.), Clinics in Endocrinology and Metabolism. Saunders Company LTD, London, 1982, p.25.
Zangeneh F., Steiner M. Oxandrolone therapy in growth retardation of children. Am. J. Dis. Child. 113:234, 1967.
Jackson S.T., Rallison M.C., Buntin W.H., Johnson S.B., Flynn R.R. Use of oxandrolone for growth stimulation in children. Am. J. Dis. Child. 126:481, 1973.
Bettman H.K., Goldman H.S., Abramowicz M., Sobel E.H. Oxandrolone treatment of short stature: effect on predicted mature height. J. Pediatr. 79:1018, 1971.
Limbeck G.A., Ruvalcaba R.H., Mahoney C.P., Kelley V.C. Studies on anabolic steroids. IV: The effect of oxandrolone on height and skeletal maturation in uncomplicated growth retardation. Clin. Pharmacol. Ther. 12:798, 1971.
Kaplan J.G., Moshang T., Bernstein R., Parks J.S., Bongiovanni A.M. Constitutional delay of growth and development: effects of treatment with androgens. J. Pediatr. 82:38, 1973.
Moore D.C., Tattoni D.S., Limbeck G.A. Studies on anabolic steroids. V: Effect of prolonged oxandrolone administration on growth in children and adolescent with uncomplicated short stature. Pediatrics 58:412, 1976.
Rosenfeld R.G., Northcraft G.B., Hintz R.L. A prospective, randomized study of testosterone treatment of constitutional delay in growth and development in male adolescent. Pediatrics 69:681, 1982.
Hophberg Z., Korman S. Oxandrolone therapy in boys of short stature. J. Pediatr. Endocrinol. 2:115, 1987.
Stanhope R., Buchanan C.R., Fenn G.C., Preece M.A. Double blind placebo controlled trial of low dose oxandrolone in the treatment of boys with constitutional delay of growth and puberty. Arch. Dis. Child. 63:501, 1988.
Clayton P.E., Shalet S.M., Price D.A., Addison G.M. Growth and growth hormone responses to Oxandrolone in boys with constitutional delay of growth and puberty (CDGP). Clin. Endocrinol. (Oxf.) 29:123, 1988.
Papadimitriou A., Wacharasindhu S. K., Preece M.A., Stanhope R. Treatment of constitutional growth delay in prepubertal boys with a prolonged course of low dose oxandrolone. Arch. Dis. Child. 66:841, 1991.
Geller J. Oxandrolone effect on growth and bone age in idiopathic growth failure. Acta Endocrinol. (Copenh.) 59:307, 1968.
Marti-Henneberg C., Niirianen A.K., Rappaport R. Oxandrolone treatment of constitutional short stature in boys during adolescence: effect on linear growth, bone age, pubic hair and testicular development. J. Pediatr. 66:783, 1975.
Blethen S.L., Gaines S., Weldon V. Comparison of predicted and adult heights in short boys: effect of androgen therapy. Pediatr. Res. 18:467, 1984.
Stanhope R., Brook C.G.D. Oxandrolone in low dose for constitutional delay of growth and puberty in boys. Arch. Dis. Child. 60:379, 1985.
Joss E.E, Schmidt H.A., Zuppinger K.A. Oxandrolone in constitutionally delayed growth, a longitudinal study up to final height. J. Clin. Endocrinol. Metab. 69:1109, 1989.
Tse W., Buyukgebiz A., Hindmarsh P.C., Stanhope R., Preece M.A., Brook C.G.D. Long-term outcome of oxandrolone treatment in boys with constitutional delay of growth and puberty. J. Pediatr. 117:588, 1990.
Wilkins L. The diagnosis and treatment of endocrine disorders in childhood and adolescence. In: Thomas C.C. Publisher, ed. 3. Springfield Ill., 1965, p. 186.
Morabito S., Nicoletti I., Marchi M., Marella M., Bianchi F. On the auxological interpretation of the percentile and the area of the normal growth. Acta Med. Auxol. 14:149, 1982.
Nicoletti I., Cheli D., Cocco E., Salvi A., Socci A. Individual skeletal profile based on percentiles of the bone stages: a method for extimating skeletal maturity. Acta Med. Auxol. 10:19, 1978.
Bayley N., Pinneau S.R. Tables for predicting adult height from skeletal age: revised for the use with the Greulich and Pyle hand standard. J. Pediatr. 40:423, 1952.
Roche A.F., Wainer H., Thissen D. Predicting adult stature for individuals. In: Falkner F., Krechmer N., Rossi E. (Eds.), Monographs in Pediatrics. Karger, Basel, 1975, p.1.
Tanner T.M., Whitehouse R.M., Cameron N., Marshall W.A., Healy M.J.R., Goldstein H. Assessment of skeletal maturity and prediction of adult height (TW2 Method), ed. 2. Academic Press, New York, 1983.
Wilson J.D. Androgen abuse by athletes. Endocr. Rev. 9:181, 1988.
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Bassi, F., Neri, A.S., Gheri, R.G. et al. Oxandrolone in constitutional delay of growth: Analisys of the growth patterns up to final stature. J Endocrinol Invest 16, 133–137 (1993). https://doi.org/10.1007/BF03347666
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DOI: https://doi.org/10.1007/BF03347666