Journal of Endocrinological Investigation

, Volume 36, Issue 6, pp 450–451 | Cite as

Insulin autoimmune syndrome induced by methimazole in a patient with Graves’ disease

  • W.-C. Zhao
  • J. Jin
  • J.-Z. Zhang
Letter to the Editor


Hypoglycemia Serum Insulin Level Methimazole Islet Cell Antibody Insulin Molecule 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Eisenbarth GS. Immunoendocrinology: Scientific and Clinical Aspects. New York, Humana Press. 2011, 343–67.CrossRefGoogle Scholar
  2. 2.
    Uchigata Y, Hirata Y, Omori Y, Iwamoto Y, Tokunaga K. Worldwide differences in the incidence of insulin autoimmune syndrome (Hirata disease) with respect to the evolution of HLA-DR4 alleles. Hum Immunol 2000, 61: 154–7.PubMedCrossRefGoogle Scholar
  3. 3.
    Uchigata Y, Hirata Y, Iwamoto Y. Drug-induced insulin autoimmune syndrome. Diabetes Res Clin Pract 2009, 83: e19–20.PubMedCrossRefGoogle Scholar
  4. 4.
    Yeung CW, Mak CM, Lam KS, Tam S. Hypoglycaemia due to autoimmune insulin syndrome in a 78-year-old Chinese man. Br J Biomed Sci 2012, 69: 80–2.PubMedCrossRefGoogle Scholar

Copyright information

© Italian Society of Endocrinology (SIE) 2013

Authors and Affiliations

  • W.-C. Zhao
    • 1
  • J. Jin
    • 2
  • J.-Z. Zhang
    • 1
  1. 1.The China-Japan Union Hospital of Jilin UniversityChangchunChina
  2. 2.Zhongshan Hospital of Fudan UniversityShanghaiChina

Personalised recommendations