Asymmetric dimethylarginine and carotid atherosclerosis in Type 2 diabetes mellitus
- 56 Downloads
Background: Circulating asymmetric dimethylarginine (ADMA) concentration is elevated in patients with Type 2 diabetes mellitus (T2DM). Aim: To assess the relationship between plasma ADMA concentration and carotid atherosclerosis in patients with T2DM. Subjects and methods: A total of 72 newly diagnosed and untreated T2DM individuals and 72 healthy controls were studied. Carotid atherosclerosis was determined by ultrasonographically evaluated intima-media thickness (IMT) and plaque score. Plasma concentration of ADMA was measured by high-performance liquid chromatography. Results: Plasma ADMA, mean IMT, and plaque score were higher in diabetic patients compared with controls. Univariate and multivariate analyses demonstrated an independent association between ADMA and mean IMT in diabetic patients. On a multiple logistic regression analysis, ADMA was the sole predictor of carotid plaque formation (plaque score ≥1.1) (odds ratio 2.43, 95% confidence interval 1.19 to 4.94, p<0.05). Conclusion: Our results suggest that increased levels of ADMA might be involved in the development of carotid atherosclerosis in T2DM.
Key-wordsAsymmetric dimethylarginine atherosclerosis intima-media thickness Type 2 diabetes mellitus
Unable to display preview. Download preview PDF.
- 5.Nanayakkara PW, Teerlink T, Stehouwer CD, et al. Plasma asymmetric dimethylarginine (ADMA) concentration is independently associated with carotid intima-media thickness and plasma soluble vascular cell adhesion molecule-1 (sVCAM-1) concentration in patients with mild-to-moderate renal failure. Kidney Int 2005, 68: 2230–6.PubMedCrossRefGoogle Scholar
- 22.Yasuda S, Miyazaki S, Kanda M, et al. Intensive treatment of risk factors in patients with type-2 diabetes mellitus is associated with improvement of endothelial function coupled with a reduction in the levels of plasma asymmetric dimethylarginine and endogenous inhibitor of nitric oxide synthase. Eur Heart J 2006, 27: 1159–65.PubMedCrossRefGoogle Scholar