Journal of Endocrinological Investigation

, Volume 9, Issue 4, pp 281–285 | Cite as

Effect of large-dose progesterone on plasma levels of lipids, lipoproteins and apolipoproteins in males

  • J. J. S. Chen
  • F. S. Berlin
  • S. Margolis
Article

Abstract

Eleven men with sexual deviation syndrome were hospitalized for treatmet with medroxyprogesterone acetate (Depo-provera). Plasma total cholesterol, triglycerides, high density lipoprotein (HDL) cholesterol, low density lipoprotein (LDL) cholesterol, apo A-I and LDL apo B were measured before and during Depo- provera treatment. Ten normolipidemic and one mildly hypertriglyceridemic patient with 117 ± 17% ideal body weight were maintained on a regular hospital diet before and during the study. They received an average total dose of 1273 ± 467 mg Depo-provera by im injections over a mean period of 17 ± 6 days. In the whole group, Depo-provera significantly reduced the plasma total cholesterol by 12% (p < 0.0005), triglycerides by 24% (p < 0.005), LDL cholesterol by 13% (p < 0.01), LDL apo B by 15% (p < 0.05), and apo A-I by 7% (p < 0.05). Total HDL cholesterol, HDL2 cholesterol and HDL3 cholesterol did not change significantly. Excluding from the data analysis a normolipidemic patient who had a significant weight loss during the study and the hypertriglyceridemic patient, the fall in apo A-I during Depo-provera treatment was no longer statistically significant. We conclude that short-term, pharmacological doses of progesterone significantly reduce plasma concentrations of cholesterol, triglycerides, LDL cholesterol, and LDL apo B in men.

Key-words

Progesterone lipids lipoproteins 

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References

  1. 1.
    Heiss G., Tamir I., Davis C., Tyroler H., Rifkind B., Schonfeld G., Jacobs D., Frantz Jr I. Lipoprotein-cholesterol distributions in selected normal American populations. The Lipid Research Clinics Program prevalence study. Circulation 61: 302, 1980.PubMedCrossRefGoogle Scholar
  2. 2.
    Cheung M.C., Albers J.J. The measurement of apolipoprotein A-l and A-ll levels in men and women by immunoassay. J. Clin. Invest. 60: 43, 1977.PubMedCentralPubMedCrossRefGoogle Scholar
  3. 3.
    Schaefer E.J., Foster D.M., Zech L.A., Lindgren F.T., Brewer Jr. H.B., Levy R.I. The effects of estrogen administration on plasma lipoprotein metabolism in premenopausal females. J. Clin. Endocrinol. Metab. 57: 262, 1983.PubMedCrossRefGoogle Scholar
  4. 4.
    Glueck C.J., Levy R.I., Fredrickson D.S. Norethindrone acetate, post-heparin lipolytic activity, and plasma triglycerides in type I, III, IV and V hyperlipoproteinemia. Ann. Intern. Med. 75: 345, 1971.PubMedCrossRefGoogle Scholar
  5. 5.
    Barth A., Klinger W. Influence of phenobarbital, chlorpromazine, progesterone and phenylbutazone on the biliary cholesterol excretion in rats. Acta Biol. Med. Ger. 39: 1217, 1980.PubMedGoogle Scholar
  6. 6.
    Amatayakul K. The effects of Depo-provera on carbohydrate, lipids and vitamin metabolism. J. Steroid Biochem. 11: 475, 1979.PubMedCrossRefGoogle Scholar
  7. 7.
    Fajumi J.D. Alterations in blood lipids and side effects induced by Depo-provera in Nigerian women. Contraception 27: 161, 1983.PubMedCrossRefGoogle Scholar
  8. 8.
    Amatayakul K., Sivassomboon B., Singkamani R. Effects of medroxyprogesterone acetate on serum lipids, protein, glucose tolerange and liver function in Thai women. Contraception 21: 283, 1980.PubMedCrossRefGoogle Scholar
  9. 9.
    Engelberg H., Glass S.J. Influence of physiologic doses of sex steroid hormones on serum lipids and lipoproteins in humans. Metabolism 4: 298, 1955.PubMedGoogle Scholar
  10. 10.
    Larsson-Cohn U., Berlin R., Vikrot O. Effects of combined and low-dose gestagen oral contraceptives on plasma lipids including individual phospholipids. Acta Endocrinol. (Kbh.) 63: 717, 1970.Google Scholar
  11. 11.
    Spellacy W.N., Buhi W.C., Birk S.A., Cabal R. The effects of estrogens, progestogen, oral contraceptives, and intrauterine devices on fasting triiglyceride and insulin levels. Fertil. Steril. 24: 178, 1973.PubMedGoogle Scholar
  12. 12.
    Donde U.M., Virkar K. The effect of combination and low dose progestogen oral contraceptives on serum lipids. Fertil. Steril. 26: 62, 1975.PubMedGoogle Scholar
  13. 13.
    Spellacy W.N., Newton R.E., Buhi W.C., Birk S.A. Carbohydrate and lipid studies during six months treatment with megestrol acetate. Am. J. Obstet. Gynecol. 116: 1074, 1973.PubMedGoogle Scholar
  14. 14.
    Lipid Research Clinics Manual of Laboratory Operations. Vol. 1 Lipid and lipoprotein analysis. Washington, DC. Government Printing Office. (9 DHEW publication no (NIH) 75-628), 1974.Google Scholar
  15. 15.
    Warnick G.R., Benderson J.M., Albers J.J. Dextran sulfate-Mg2+ precipitation procedure for quantitation of high density lipoprotein cholesterol. Clin. Chem. 28: 1379, 1982.PubMedGoogle Scholar
  16. 16.
    Friedewald W.T., Levy R.I., Fredrickson D.S. Estimation of the concentration of low-density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge. Clin. Chem. 18: 499, 1972.PubMedGoogle Scholar
  17. 17.
    Maciejko J.J., Holmes D.R., Kottke B.A., Zinsmeister A.R., Dinh D.M., Mao S.J.T. Apolipoprotein A-l as a marker of angiographically assessed coronary artery disease. N. Engl. J. Med. 309: 385, 1983.PubMedCrossRefGoogle Scholar
  18. 18.
    Berlin F.S., Meinecke OF. Treatment of sex offenders with antiandrogenic medication: conceptualization, review of treatment modalities, and preliminary findings. Am. J. Psychiatry 138: 601, 1981.PubMedGoogle Scholar
  19. 19.
    Rivarola M.A., Camacho A.M., Migeon C.J. Effect of treatment with medroxyprogesterone acetate (Provera) on testicular function. J. Clin. Endocrinol. Metab. 28: 679, 1968.PubMedCrossRefGoogle Scholar
  20. 20.
    Gutai J., LaPorte R., Kuller L., Dai W., Falvo-Gerard L., Caggiula A. Plasma testosterone, high density lipoprotein cholesterol and other lipoprotein fractions. Am. J. Cardiol. 48: 897, 1981.PubMedCrossRefGoogle Scholar
  21. 21.
    Goldberg R.B., Rabirr D., Alexander A.N., Doelle G.C., Getz G.S. Suppression of plasma testosterone leads to an increase in serum total and high density lipoprotein cholesterol and apoproteins A-l and B. J. Clin. Endocrinol. Metab. 60: 203, 1985.PubMedCrossRefGoogle Scholar
  22. 22.
    Wahl P., Waiden C., Knopp R., Hoover J., Wallace R., Heiss G., Rifkind B. Effect of estrogen/progestin potency on lipid/lipoprotein cholesterol. N. Engl. J. Med. 308: 862, 1983.PubMedCrossRefGoogle Scholar
  23. 23.
    Hirvonen E., Malkonen M., Manninen V. Effects of different progestogens on lipoproteins during postmenopausal replacement therapy. N. Engl. J. Med. 304: 560, 1981.PubMedCrossRefGoogle Scholar
  24. 24.
    Silfverstolpe G., Gustafson A., Samsioe G., Svanborg A. Lipid metabolic studies in oophorectomized women: Effects of three different progestogens. Acta Obstet. Gynecol. Scand. (Suppl.) 88: 89, 1979.CrossRefGoogle Scholar

Copyright information

© Italian Society of Endocrinology (SIE) 1986

Authors and Affiliations

  • J. J. S. Chen
    • 1
  • F. S. Berlin
    • 1
  • S. Margolis
    • 1
  1. 1.Departments of Medicine and Psychiatry and Behavioral SciencesJohns Hopkins University School of MedicineBaltimoreUSA

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