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Recurrent thromboembolism as a hallmark of Cushing’s syndrome

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Abstract

The present report describes a 54-year-old woman with a history of recurrent thromboembolic events. The clinical and physical examination led to suspect Cushing’s syndrome. Screening tests (urinary free Cortisol excretion and 1 mg dexamethasone) were inconclusive, but a detailed endocrine work up confirmed the presence of ACTH-dependent hypercortisolism. The patient was cured by the removal of a ACTH-secreting microadenoma by transsphenoidal route. The present case provides a clinical demonstration of a previous experimental evidence that a hypercoagulable state is present in Cushing’s syndrome.

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Authors and Affiliations

  1. Divisione di Medicina Interna e Servizio di Endocrinologia e Malattie del Metabolismo, Ospedale Civile di Giaveno, Italy

    A. La Brocca M.D.

  2. Dipartimento di Scienze Cliniche e Biologiche, Cattedra di Medicina Interna, Università di Torino, Torino, Italy

    M. Terzolo, A. Pia, P. Paccotti & A. Angeli

  3. Dipartimento di Servizio di Anatomia ed Istologia Patologica, Azienda Ospedaliera San Luigi Gonzaga, Università di Torino, Torino, Italy

    P. De Giuli

Authors
  1. A. La Brocca M.D.
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  2. M. Terzolo
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  3. A. Pia
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  4. P. Paccotti
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  5. P. De Giuli
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  6. A. Angeli
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La Brocca, A., Terzolo, M., Pia, A. et al. Recurrent thromboembolism as a hallmark of Cushing’s syndrome. J Endocrinol Invest 20, 211–214 (1997). https://doi.org/10.1007/BF03346905

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