Abstract
The different factors involved as etiological agents in thyroid cancer have in common long term thyroid follicle stimulation. On this base, a patient with a TSH-producing pituitary adenoma could be at high risk for developing thyroid cancer. A patient consulting for a single thyroid nodule was studied in our unit. He was diagnosed as having a TSH-producing pituitary adenoma and the Thyroid nodule was shown to be a follicular carcinoma following removed. We speculate that elevated TSH levels could have contributed to neoplastic transformation of the thyroid in this patient.
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References
DeGroot L.J., Sridama V. Thyroid neoplasia. In: DeGroot L.J. (Ed.), Endocrinology. W.B. Saunders Company, Philadelphia, 1989, p. 758.
Studer H., Peter H.J., Gerber H. Natural heterogeneity of thyroid cells: The basis for understanding thyroid function and nodular goiter growth. Endocr. Rev. 10: 125, 1989.
Thomas G.A., Williams D., Williams E.D. The demonstration of tissue clomality by X-linked enzyme histochemistry. J. Pathol. 155: 101, 1988.
Mazzaferri E. Papillary thyroid carcinoma: Factors influencing prognosis and current therapy. Sem. Oncology 14: 315, 1987.
Benker G., Olbricht Th., Reinwein D., Reiners Chr., Sauerwein W., Krause U., Mlynek M.L., Hirche H. Survival rates in patients with differentiated thyroid carcinoma. Cancer 65: 1517, 1990.
Comi R.J., Gesundheit N., Murray L., Gorden P., Weintraub B.D. Response of thyrotropin-secreting pituitary pituitary adenoma to a long-acting somatostatin analogue. N. Engl. J. Med. 317: 12, 1987.
Lamberts S.W.J. The role of somatostatine in the regulation of anterior pituitary hormone secretion and the use of its analogs in the treatment of human pituitary tumors. Endocr. Rev. 9: 417, 1988.
Gesundheit N., Petrick P.A., Nissim M., Dahlberg P.A., Doppman J.L., Emerson Ch. H., Braverman L.E., Oldfield E.H., Weintraub B.D. Thyrotropin-secreting pituirary adenomas: Clinical and biochemical heterogeneity. Ann. Intern. Med. 111: 827, 1989.
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Calle-Pascual, A.L., Yuste, E., Martin, P. et al. Association of a thyrotropin-secreting pituitary adenoma and a thyroid follicular carcinoma. J Endocrinol Invest 14, 499–502 (1991). https://doi.org/10.1007/BF03346852
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DOI: https://doi.org/10.1007/BF03346852