Advertisement

Journal of Endocrinological Investigation

, Volume 14, Issue 6, pp 499–502 | Cite as

Association of a thyrotropin-secreting pituitary adenoma and a thyroid follicular carcinoma

  • A. L. Calle-Pascual
  • E. Yuste
  • P. Martin
  • T. Aramendi
  • M. L. Garcia-Mauriño
  • J. Argente
  • M. J. Catalan
  • J. Uria
  • J. A. Cabranes
  • A. L. Charro
Case Report

Abstract

The different factors involved as etiological agents in thyroid cancer have in common long term thyroid follicle stimulation. On this base, a patient with a TSH-producing pituitary adenoma could be at high risk for developing thyroid cancer. A patient consulting for a single thyroid nodule was studied in our unit. He was diagnosed as having a TSH-producing pituitary adenoma and the Thyroid nodule was shown to be a follicular carcinoma following removed. We speculate that elevated TSH levels could have contributed to neoplastic transformation of the thyroid in this patient.

Key-words

TSH pituitary adenoma thyroid cancer 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    DeGroot L.J., Sridama V. Thyroid neoplasia. In: DeGroot L.J. (Ed.), Endocrinology. W.B. Saunders Company, Philadelphia, 1989, p. 758.Google Scholar
  2. 2.
    Studer H., Peter H.J., Gerber H. Natural heterogeneity of thyroid cells: The basis for understanding thyroid function and nodular goiter growth. Endocr. Rev. 10: 125, 1989.PubMedCrossRefGoogle Scholar
  3. 3.
    Thomas G.A., Williams D., Williams E.D. The demonstration of tissue clomality by X-linked enzyme histochemistry. J. Pathol. 155: 101, 1988.PubMedCrossRefGoogle Scholar
  4. 4.
    Mazzaferri E. Papillary thyroid carcinoma: Factors influencing prognosis and current therapy. Sem. Oncology 14: 315, 1987.Google Scholar
  5. 5.
    Benker G., Olbricht Th., Reinwein D., Reiners Chr., Sauerwein W., Krause U., Mlynek M.L., Hirche H. Survival rates in patients with differentiated thyroid carcinoma. Cancer 65: 1517, 1990.PubMedCrossRefGoogle Scholar
  6. 6.
    Comi R.J., Gesundheit N., Murray L., Gorden P., Weintraub B.D. Response of thyrotropin-secreting pituitary pituitary adenoma to a long-acting somatostatin analogue. N. Engl. J. Med. 317: 12, 1987.PubMedCrossRefGoogle Scholar
  7. 7.
    Lamberts S.W.J. The role of somatostatine in the regulation of anterior pituitary hormone secretion and the use of its analogs in the treatment of human pituitary tumors. Endocr. Rev. 9: 417, 1988.PubMedCrossRefGoogle Scholar
  8. 8.
    Gesundheit N., Petrick P.A., Nissim M., Dahlberg P.A., Doppman J.L., Emerson Ch. H., Braverman L.E., Oldfield E.H., Weintraub B.D. Thyrotropin-secreting pituirary adenomas: Clinical and biochemical heterogeneity. Ann. Intern. Med. 111: 827, 1989.PubMedCrossRefGoogle Scholar

Copyright information

© Italian Society of Endocrinology (SIE) 1991

Authors and Affiliations

  • A. L. Calle-Pascual
    • 1
    • 6
  • E. Yuste
    • 1
  • P. Martin
    • 1
  • T. Aramendi
    • 2
  • M. L. Garcia-Mauriño
    • 2
  • J. Argente
    • 3
  • M. J. Catalan
    • 3
  • J. Uria
    • 4
  • J. A. Cabranes
    • 5
  • A. L. Charro
    • 5
  1. 1.Unidad de Endocrinologia y NutricionAvilaSpain
  2. 2.Seccion de Anatomia PatologicaUniversidad de SalamancaAvilaSpain
  3. 3.Unidad de Neurologia, Hospital Ntra Sra de SonsolesUniversidad de SalamancaAvilaSpain
  4. 4.Servicio de Neurocirugia, Clinica Puerta de HierroHospital Clinico San CarlosMadridSpain
  5. 5.Servicio de Endocrinologia y Medicina NuclearHospital Clinico San CarlosMadridSpain
  6. 6.Servicio de Endocrinologia y NutricionHospital Clinico de San CarlosMadridSpain

Personalised recommendations