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Journal of Endocrinological Investigation

, Volume 14, Issue 3, pp 241–244 | Cite as

Role of growth hormone-releasing hormone on pentagastrin-induced growth hormone release in normal subjects

  • J. F. Garcia-Rojas
  • A. Mangas
  • A. Barba
  • J. Millan
  • C. Dieguez
  • E. Zamora
Comment

Abstract

In order to investigate the mechanisms by which gastrin cause GH release in humans we measured the GH response to pentagastrin alone (1.5 µg/kg/hour from 120 to 210 min) and following pretreatment with GHRH (GHRH 1-29,250 µg, iv at 0 min) in normal male subjects. Prior GHRH administration abolished the GH response to the second bolus of GHRH (1 µg/kg) administered two hours later Pentagastrin infusion induced a rise in GH levels maximal at 60 min (9.1+0.6 ng/ml, mean+SE), but this rise was abolished by pretreatment with GHRH. Finally, we found that gastrin did not modify basal GH release or GH responses to GHRH by rat anterior pituitary cells in monolayer culture. Taken together, these data suggest that gastrin regulates GH secretion by acting at hypothalamic level.

Key-words

Gastrin growth hormone growth hormone-releasing hormone 

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Copyright information

© Italian Society of Endocrinology (SIE) 1991

Authors and Affiliations

  • J. F. Garcia-Rojas
    • 1
  • A. Mangas
    • 1
  • A. Barba
    • 1
  • J. Millan
    • 1
  • C. Dieguez
    • 2
  • E. Zamora
    • 1
  1. 1.Department of Medicine, Faculty of MedicineUniversity of CadizCadizSpain
  2. 2.Department of Physiology, Faculty of MedicineUniversity of SantiagoSantiago de CompostelaSpain

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