Journal of Endocrinological Investigation

, Volume 14, Issue 3, pp 209–212 | Cite as

Identification of a subgroup of Graves’ disease patients at higher risk for severe ophthalmopathy after radioiodine

  • A. Barth
  • P. Probst
  • H. Bürgi


We have analyzed retrospectively the records of 89 patients with Graves’ disease who were treated with radioiodine between 1980–88 and whose ophthalmopathy was recorded in a uniform manner initially and after 5 and 12 months. Moreover information on progression of eye disease was obtained by telephone for all patients after an average of 72 months. Pretreatment endocrine ophthalmopathy (class ≥ 1 of classification of American Thyroid Association) was present in 34% of the patients. Eight patients developed proptosis over 20mm, 7 patients severe ophthalmopathy (classes 4 to 6), 5 patients required special treatment for eye disease. Among the 30 patients with initial ophthalmopathy, severe ophthalmopathy (5 of 30; p < 0.05) and proptosis > 20mm 16 of 30; p < 0.05) developed in significantly more cases than in patients with no pretreatment ophthalmopathy. The data suggest that hyperthyroid patients with pretreatment ophthalmopathy are at risk for developing severe ophthalmopathy after 131I treatment.


Graves’ disease radioiodine endocrine ophthalmopathy exophthalmos 


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Copyright information

© Italian Society of Endocrinology (SIE) 1991

Authors and Affiliations

  • A. Barth
    • 1
  • P. Probst
    • 2
  • H. Bürgi
    • 1
  1. 1.Department of MedicineBürgerspitalSolothurnSwitzerland
  2. 2.Institute for Medical RadiologyBürgerspitalSolothurnSwitzerland

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