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Journal of Endocrinological Investigation

, Volume 32, Issue 11, pp 870–872 | Cite as

Prolonged treatment with N-acetylcysteine and L-arginine restores gonadal function in patients with polycistic ovary syndrome

  • A. Masha
  • C. Manieri
  • S. Dinatale
  • G. A. Bruno
  • E. Ghigo
  • V. Martina
Rapid Communication

Abstract

Nitric oxide (NO) plays a wide spectrum of biological actions including a positive role in oocyte maturation and ovulation. Free radicals levels have been shown elevated in polycistic ovary syndrome (PCOS) and therefore would be responsible for quenching NO that, in turn, would play a role in determining oligo- or amenorrhea connoting PCOS. Eight patients with PCOS displaying oligo-amenorrhea from at least 1 yr underwent a combined treatment with N-acetylcysteine (NAC) (1200 mg/die) plus L-arginine (ARG) (1600 mg/die) for 6 months. Menstrual function, glucose and insulin levels, and, in turn, homeostasis model assessment (HOMA) index were monitored. Menstrual function was at some extent restored as indicated by the number of uterine bleedings under treatment (3.00, 0.18–5.83 vs 0.00, 0.00–0.83; p<0.02). Also, a well-defined biphasic pattern in the basal body temperature suggested ovulatory cycles. The HOMA index decreased under treatment (2.12, 1.46–4.42 vs 3.48, 1.62–5.95; p<0.05). In conclusion, this preliminary, open study suggests that prolonged treatment with NAC+ARG might restore gonadal function in PCOS. This effect seems associated to an improvement in insulin sensitivity.

Keywords

L-arginine N-acetylcysteine PCOS 

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Copyright information

© Italian Society of Endocrinology (SIE) 2009

Authors and Affiliations

  • A. Masha
    • 1
  • C. Manieri
    • 1
  • S. Dinatale
    • 1
  • G. A. Bruno
    • 1
  • E. Ghigo
    • 1
  • V. Martina
    • 1
  1. 1.Division of Endocrinology, Department of Internal MedicineUniversity of TurinTurinItaly

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