Journal of Endocrinological Investigation

, Volume 31, Issue 7, pp 614–617 | Cite as

Thyroid volume is associated with family history of thyroid disease in pregnant women with adequate iodine intake: A cross-sectional study in southern Brazil

  • R. Soares
  • R. Vanacor
  • D. Manica
  • L. B. Dorneles
  • V. L. Resende
  • M. C. Bertoluci
  • T. W. Furlanetto
Original Articles


Maternal euthyroidism is important for fetal neural development. For this reason, adequate iodine nutrition during pregnancy is an important public health objective and should be periodically revised. The objective of this study was to measure urinary iodine (UI) excretion and the factors associated with thyroid volume (TV), in a group of healthy pregnant women in southern Brazil, to evaluate iodine nutrition. The median UI of the 147 women was 224 µg/l (P25=164 µg/l and P75=286 µg/l). Serum levels of free T4 and thyroglobulin did not correlate with UI, but there was a weak inverse correlation between serum TSH levels and UI (r=−0.200; p=0.02). TV, calculated through ultrasound in 57 women, was significantly associated with family history of thyroid diseases (p=0.002) and BMI (p=0.03), but there was no association with UI, corrected or not for creatinine, serum free T4, TSH or thyroglobulin, current or past smoking, gestational age, parity or oral contraceptive. Conclusions: The healthy pregnant women studied had adequate iodine intake. In this situation, the main thyroid size determinants are probably genetic factors.


Family history of thyroid disease iodine pregnancy thyroid volume 


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Copyright information

© Italian Society of Endocrinology (SIE) 2008

Authors and Affiliations

  • R. Soares
    • 1
  • R. Vanacor
    • 1
  • D. Manica
    • 2
  • L. B. Dorneles
    • 2
  • V. L. Resende
    • 3
  • M. C. Bertoluci
    • 1
    • 2
  • T. W. Furlanetto
    • 1
    • 2
  1. 1.Post-Graduation Program in Medicine: Medical SciencesBrazil
  2. 2.Division of Internal MedicineFederal University of Rio Grande do SulPorto AlegreBrazil
  3. 3.Division of Radiology, Hospital de Clínicas de Porto AlegreFederal University of Rio Grande do SulPorto AlegreBrazil

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