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Journal of Endocrinological Investigation

, Volume 35, Issue 4, pp 357–358 | Cite as

Effect of physiological exercise on osteocalcin levels in subjects with adrenal incidentaloma

  • V. Coiro
  • R. Volpi
  • S. Cataldo
  • M. G. Magotti
  • M. L. Maffei
  • C. Giumelli
  • A. Araldi
  • L. Volpi
  • P. Chiodera
Rapid Communication

Abstract

Aim: In the present study, we have evaluated whether physical exercise affect low osteocalcin concentrations observed in patients with subclinical hypercortisolism. Subjects and methods: Sixteen patients (10 men and 6 women, age 38–55 yr) with adrenal incidentaloma were studied. Fifteen healthy volunteers matched for age (range 35–47 yr) were used as controls. Subjects were submitted to a 8-week exercise-training program with cycle-ergometer for 1 h/day 3–4 days/week at 60% of their individual VO2 max. Before and after this period, resting venous serum osteocalcin and GH concentrations were measured in the same batch. The blood sampling after 8 weeks of the training program were performed after resting for one day. All patients and controls underwent also the following endocrine evaluation: serum cortisol, plasma ACTH. Results: Our results demonstrate a significant increase of osteocalcin after physical exercise and a positive correlation between osteocalcin and GH. This later might suggest a role of GH in the increased osteocalcin secretion. Conclusions: The data of the present study suggest a positive effect of physical exercise on bone metabolism in patients with adrenal incidentaloma.

Key-words

Adrenal incidentaloma osteocalcin physical exercise 

References

  1. 1.
    Guadalupe-Grau A, Fuentes T, Guerra B, Calbet JA. Exercise and bone mass in adults. Sport Med 2009, 39: 439–68.CrossRefGoogle Scholar
  2. 2.
    Osella G, Terzolo M, Reimondo G, et al. Serum markers of bone and collagen turnover in patients with Cushing’s syndrome and in subjects with adrenal incidentalomas. J Clin Endocrinol Metab 1997, 82: 3303–7.PubMedGoogle Scholar
  3. 3.
    Francucci CM, Caudarella R, Rilli S, Fiscaletti P, Ceccoli L, Boscaro M. Adrenal incidentaloma: effects on bone metabolism. J Endocrinol Invest 2008, 31(Suppl 7): 48–52.PubMedGoogle Scholar
  4. 4.
    Epstein S. Serum and urinary markers of bone remodeling: assessment of bone turnover. Endocr Rev 1998, 9: 437–49.CrossRefGoogle Scholar
  5. 5.
    Schaible TF, Scheuer J. Cardiac adaptation to chronic exercise. Prog Cardiovasc Dis 1985, 27: 297–324.PubMedCrossRefGoogle Scholar

Copyright information

© Italian Society of Endocrinology (SIE) 2012

Authors and Affiliations

  • V. Coiro
    • 1
  • R. Volpi
    • 1
  • S. Cataldo
    • 1
  • M. G. Magotti
    • 2
  • M. L. Maffei
    • 3
  • C. Giumelli
    • 1
  • A. Araldi
    • 1
  • L. Volpi
    • 1
  • P. Chiodera
    • 1
    • 2
  1. 1.Dept. Internal Medicine and Biomedical SciencesUniversity of ParmaParmaItaly
  2. 2.Endocrine ServiceHospital of ParmaParmaItaly
  3. 3.Cardiology UnitHospital of ParmaParmaItaly

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