Journal of Endocrinological Investigation

, Volume 28, Issue 2, pp 984–989 | Cite as

Hypopituitarism induced by traumatic brain injury in the transition phase

  • G. Aimaretti
  • M. R. Ambrosio
  • C. Di Somma
  • M. Gasperi
  • S. Cannavò
  • C. Scaroni
  • L. De Marinis
  • R. Baldelli
  • G. Bona
  • G. Giordano
  • E. Ghigo
Original Article


Traumatic brain injury (TBI) has been associated with hypopituitarism in general and GH deficiency (GHD) in particular; the consequences of this on growth and development are likely to be critical in children and adolescents in the so-called “transition phase”. In order to verify the consequences of TBI on pituitary function in the transition phase, we studied a population of adolescents and young adults 3 and 12 months after brain injury [no.=23, 9 females, 14 males; age: 16-25 yr; body mass index (BMI): 21.9±0.6 kg/m2]. At 3 months, hypopituitarism was present in 34.6%. Total, multiple and isolated deficits were present in 8.6, 4.3 and 21.7%, respectively. Diabetes insipidus (DI) was present in 8.6% patients and mild hyperprolactinemia in 4.3%. At 12 months, hypopituitarism was present in 30.3%. Total, multiple and isolated deficits were present in 8.6, 4.3 and 17.4%, respectively. DI was present in 4.3% of patients and mild hyperprolactinemia in 4.3%. Total hypopituitarism was always confirmed at retesting. Multiple and isolated hypopituitarism were confirmed in 0/1 and 2/5, respectively. Two/23 patients showed isolated hypopituitarism at 12 months only; 1 patient with isolated at 3 months showed multiple hypopituitarism at retesting. GHD and secondary hypogonadism were the most common acquired pituitary deficits. These results show the high risk of TBI-induced hypopituitarism also in the transition age. Thus it is recommended that pediatric endocrinologists follow-up pituitary function of children and adolescents after brain injuries.


Traumatic brain injury hypopituitarism adolescence transition phase 


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Copyright information

© Italian Society of Endocrinology (SIE) 2005

Authors and Affiliations

  • G. Aimaretti
    • 1
  • M. R. Ambrosio
    • 2
  • C. Di Somma
    • 3
  • M. Gasperi
    • 4
  • S. Cannavò
    • 5
  • C. Scaroni
    • 6
  • L. De Marinis
    • 7
  • R. Baldelli
    • 1
    • 8
  • G. Bona
    • 8
  • G. Giordano
    • 9
  • E. Ghigo
    • 1
  1. 1.1Division of Endocrinology and Metabolism, Department of Internal MedicineUniversity of TurinTurinItaly
  2. 2.Department of Biomedical Sciences and Advanced Therapies, Section of EndocrinologyUniversity of FerraraFerraraItaly
  3. 3.Department of Molecular and Clinical Endocrinology and OncologyUniversity of Naples “Federico II”NaplesItaly
  4. 4.Department of Endocrinology and MetabolismUniversity of PisaPisaItaly
  5. 5.Section of Endocrinology, Department of Medicine and PharmacologyUniversity of MessinaMessinaItaly
  6. 6.Division of Endocrinology, Department of Surgical and Medical SciencesUniversity of PaduaPaduaItaly
  7. 7.Division of EndocrinologyCatholic UniversityRomeItaly
  8. 8.Division of PaediatricsUniversity of Piemonte Orientale “A. Avogadro”NovaraItaly
  9. 9.Italian Society of EndocrinologyItaly

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