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Journal of Endocrinological Investigation

, Volume 26, Issue 2, pp 181–186 | Cite as

Testosterone and coronary vascular tone: Implications in coronary artery disease

  • F. L. Wynne
  • Raouf A. Khalil
Short Review

Abstract

The greater incidence of coronary artery disease in men compared to women has often suggested possible harmful effects of male sex steroids that could promote coronary atherogenesis and vasoconstriction. However, antiatherogenic and coronary vasodilator effects of testosterone have also been suggested. The interaction of testosterone (T) with its specific receptors may trigger not only long-term genomic effects, but also acute non-genomic vasodilator responses. Testosterone may activate the endothelium and stimulate the nitric oxide-cGMP and/or the hyperpolarization-mediated vascular relaxation pathway. T may also inhibit the signaling mechanisms of smooth muscle contraction such as [Ca2+]i and protein kinases. The T-induced stimulation of endothelium-dependent mechanisms of vascular relaxation and inhibition of the mechanisms of coronary smooth muscle contraction represent potential beneficial effects of T against coronary artery disease.

Key words

Androgens coronary artery endothelium smooth muscle signal transduction 

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Copyright information

© Italian Society of Endocrinology (SIE) 2003

Authors and Affiliations

  1. 1.Research and DevelopmentDepartment of Veterans Affairs Medical center and Harvard Medical School West RoxburyUSA

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