EP1572: A novel peptido-mimetic GH secretagogue with potent and selective GH-releasing activity in man
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EP1572 (JMV1843 [Aib-DTrp-DgTrp-CHO]) is a new peptido-mimetic GH secretagogue (GHS) showing binding potency to the GHS-receptor in animal and human tissues similar to that of ghrelin and peptidyl GHS. EP1572 induces marked GH increase after sc administration in neonatal rats. Preliminary data in 2 normal young men show that: 1) acute iv EP1572 administration (1.0 μg/kg) induces strong and selective increase of GH levels; 2) single oral EP1572 administration strongly and reproducibly increases GH levels even after a dose as low as 0.06 mg/kg. Thus, EP1572 is a new peptido-mimetic GHS with potent and selective GH-releasing activity.
Key-wordsSynthetic GH secretagogues GH ghrelin receptors oral administration humans
- 5.Martinez J., Fehrentz J.A., Guerlavais V. Growth hormone secretagogues, PCT — WO 01/96300 A1, 20.12.2001Google Scholar