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Journal of Endocrinological Investigation

, Volume 25, Issue 8, pp RC26–RC28 | Cite as

EP1572: A novel peptido-mimetic GH secretagogue with potent and selective GH-releasing activity in man

  • F. Broglio
  • F. Boutignon
  • A. Benso
  • C. Gottero
  • F. Prodam
  • E. Arvat
  • C. Ghè
  • F. Catapano
  • A. Torsello
  • V. Locatelli
  • G. Muccioli
  • D. Boeglin
  • V. Guerlavais
  • J. A. Fehrentz
  • J. Martinez
  • E. Ghigo
  • R. Deghenghi
Rapid Communication

Abstract

EP1572 (JMV1843 [Aib-DTrp-DgTrp-CHO]) is a new peptido-mimetic GH secretagogue (GHS) showing binding potency to the GHS-receptor in animal and human tissues similar to that of ghrelin and peptidyl GHS. EP1572 induces marked GH increase after sc administration in neonatal rats. Preliminary data in 2 normal young men show that: 1) acute iv EP1572 administration (1.0 μg/kg) induces strong and selective increase of GH levels; 2) single oral EP1572 administration strongly and reproducibly increases GH levels even after a dose as low as 0.06 mg/kg. Thus, EP1572 is a new peptido-mimetic GHS with potent and selective GH-releasing activity.

Key-words

Synthetic GH secretagogues GH ghrelin receptors oral administration humans 

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Copyright information

© Italian Society of Endocrinology (SIE) 2002

Authors and Affiliations

  • F. Broglio
    • 1
  • F. Boutignon
    • 2
  • A. Benso
    • 1
  • C. Gottero
    • 1
  • F. Prodam
    • 1
  • E. Arvat
    • 1
  • C. Ghè
    • 3
  • F. Catapano
    • 3
  • A. Torsello
    • 4
  • V. Locatelli
    • 4
  • G. Muccioli
    • 3
  • D. Boeglin
    • 5
  • V. Guerlavais
    • 5
  • J. A. Fehrentz
    • 5
  • J. Martinez
    • 5
  • E. Ghigo
    • 1
  • R. Deghenghi
    • 2
  1. 1.Divisione di Endocrinologia, Department of Internal MedicineUniversity of TurinItaly
  2. 2.Europeptides, ArgenteuilUniversités MontpellierFrance
  3. 3.Departments of Anatomy, Pharmacol. and Forensic MedicineUniversity of TurinTurinItaly
  4. 4.Department of Experimental and Environmental Medicine and BiotechnologiesUniversity Milano-BicoccaMilanItaly
  5. 5.Laboratoire des Aminoacides, Peptides et ProtéinesUniversités MontpellierFrance

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