Journal of Endocrinological Investigation

, Volume 25, Issue 7, pp 578–585 | Cite as

Immunohistochemical detection of E-cadherin, α- and β-catenins in papillary thyroid carcinoma

  • Y. Kapran
  • Nese Özbey
  • S. Molvalilar
  • E. Sencer
  • F. Dizdaroğlu
  • S. Özarmağan
Original Article


E-cadherin and catenins play a major role in neoplastic cell behavior as a suppressor of invasion and/or metastasis. The aim of this study was to determine E-cadherin, α-catenin and β-catenin expressions in papillary thyroid carcinoma (PTC) and to correlate the results of expression to initial clinicopathological parameters and clinical outcome. Forty-one cases (mean age 37.3±11.2 yr) with PTC were studied. Patients were followed-up with a mean period of 47.6±27.0 months. A retrospective immunohistochemical analysis of E-cadherin, α-catenin and β-catenin was performed on paraffin-embedded tissue sections. Tissues from ten patients with benign goiter were used as controls. E-cadherin, α- and β-catenin immunoreactivities were found in 80% (33/41), 76% (31/41) and 97% (40/41) of patients respectively. No correlation was found between E-cadherin, α- and β-catenin immunoreactivities and sex, local invasion or lymphatic spread at the time of initial examination. Distant metastases and/or local recurrences developed in 6 patients during follow-up. Recurrences/metastases developed both E-cadherin, α- and β-catenin positive and negative primary tumors. Disease-free survival curves according to Kaplan-Meier analysis and log-rank test did not show any significant differences between E-cadherin, α- and β-catenin positive and negative patients. According to our findings, E-cadherin, α- and β-catenin expressions may not add any valuable information to the follow-up in a subgroup of PTC patients with a relatively benign course.


E-cadherin a-catenin β-catenin thyroid cancer prognosis 


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Copyright information

© Italian Society of Endocrinology (SIE) 2002

Authors and Affiliations

  • Y. Kapran
    • 1
  • Nese Özbey
    • 1
  • S. Molvalilar
    • 2
  • E. Sencer
    • 2
  • F. Dizdaroğlu
    • 1
  • S. Özarmağan
    • 3
  1. 1.Department of PathologyTozkoparan Mah., Kopuz Sokak, Cevahir Koru Sitesi, D BlokMerter/IstanbulTurkey
  2. 2.Department of Internal Medicine, Division of EndocrinologyIstanbul Faculty of MedicineIstanbulTurkey
  3. 3.Department of General SurgeryIstanbul Faculty of MedicineIstanbulTurkey

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