Riassunto
L’eritropoietina è un ormone glicoproteico d’origine renale che regola la produzione di globuli rossi. Le eritropoietine usate nella terapia dell’anemia da insufficienza renale e nei pazienti neoplastici sono preparate con tecniche ricombinanti mediante transfezione del gene umano in cellule di mammifero. Di conseguenza le eritropoietine ricombinanti possiedono un maggior contenuto zuccherino. Quest a caratteristica le rende riconoscibili nelle urine mediante tecniche immunoelettroforetiche. Ancor meglio riconoscibile è la darbopoietina perché possiede un maggior numero di molecole d’acido sialico. Le suddette tecniche sono quindi impiegate per rivelare l’uso di eritropoietine nel doping degli atleti.
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Buonamano, A., Romagnani, P. Doping con eritropoietina . L’Endocrinologo 4, 90–92 (2003). https://doi.org/10.1007/BF03344455
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DOI: https://doi.org/10.1007/BF03344455