Journal of Endocrinological Investigation

, Volume 29, Issue 6, pp 555–559 | Cite as

Coexistence of TSH-secreting pituitary adenoma and autoimmune hypothyroidism

  • M. Losa
  • P. Mortini
  • R. Minelli
  • M. Giovanelli
Case Report


Objective: TSH-secreting pituitary adenomas account for about 1–2% of all pituitary adenomas. Their diagnosis may be very difficult when coexistence of other diseases masquerades the clinical and biochemical manifestations of TSH-hypersecretion. Clinical presentation: A 41-yr-old female patient, weighing 56 kg, was referred for evaluation of an intra- and suprasellar mass causing menstrual irregularities. Eight yr before, the patient had been given a diagnosis of subclinical autoimmune hypothyroidism because of slightly elevated TSH levels and low-normal free T4 (FT4). Menses were normal. Despite increasing doses of levo-T4 (L-T4; up to 125 µg/day), TSH levels remained elevated and the patient developed mild symptoms of hyperthyroidism. After 7 yr, the menstrual cycle ceased. Gonadotropins were normal, whereas PRL level was elevated at 70 µg/l and magnetic resonance imaging (MRI) of the hypothalamic-pituitary region revealed a pituitary lesion with slight suprasellar extension. The tumor was surgically removed and histological examinations revealed a pituitary adenoma strongly positive for TSH. Three months after surgery the patient was well while receiving L-T4 75 µg/day and normal menses had resumed. MRI of the hypothalamic-pituitary region showed no evidence of residual tumor. At the last follow-up, 16 months after surgery, serum TSH, free T3 (FT3), and FT4 levels were normal. Conclusions: Coexistence of autoimmune hypothyroidism and TSH-secreting pituitary adenoma may cause further delays in the diagnosis of the latter. In patients with autoimmune hypothyroidism, one should be aware of the possible presence of a TSH-secreting pituitary adenoma when TSH levels do not adequately suppress in the face of high doses of L-T4 replacement therapy and elevated serum thyroid hormone levels.


Pituitary neoplasm pituitary surgery thyrotropin thyroid 


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Copyright information

© Italian Society of Endocrinology (SIE) 2006

Authors and Affiliations

  • M. Losa
    • 1
  • P. Mortini
    • 1
  • R. Minelli
    • 2
  • M. Giovanelli
    • 1
  1. 1.Pituitary Unit, Department of Neurosurgery, Istituto Scientifico San RaffaeleUniversità Vita-SaluteMilano
  2. 2.Endocrinology Unit, Department of Internal Medicine and Biomedical ScienceUniversità degli Studi di ParmaParmaItaly

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