Journal of Endocrinological Investigation

, Volume 29, Issue 2, pp 172–176 | Cite as

Paraadrenal Castleman disease presenting with adrenal hyperandrogenism

  • K. Müssig
  • B. Gallwitz
  • F. Machicao
  • M. Horger
  • H. U. Häring
  • E. Kaiserling
Case Report


Castleman disease, or angiofollicular lymph node hyperplasia, is a rare benign lymphoproliferative disorder. We report an uncommon case of retroperitoneal Castleman syndrome associated with adrenal hyperandrogenism and with interleukin-6 as the possible link in the pathophysiology of both disturbances. Four years after surgical resection of the paraadrenal mass, the patient is free of signs of recurrence of Castleman disease and adrenal hyperandrogenism.


Castleman disease hyaline vascular type angiofollicular lymph node hyperplasia adrenal hyperandrogenism interleukin-6 


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Copyright information

© Italian Society of Endocrinology (SIE) 2006

Authors and Affiliations

  • K. Müssig
    • 1
  • B. Gallwitz
    • 1
  • F. Machicao
    • 1
  • M. Horger
    • 2
  • H. U. Häring
    • 1
  • E. Kaiserling
    • 3
  1. 1.Division of Endocrinology, Metabolism and PathobiochemistryDepartment of Internal MedicineGermany
  2. 2.Department of Diagnostic RadiologyGermany
  3. 3.Department of General PathologyUniversity Hospital of TübingenTübingenGermany

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