Paraadrenal Castleman disease presenting with adrenal hyperandrogenism
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Castleman disease, or angiofollicular lymph node hyperplasia, is a rare benign lymphoproliferative disorder. We report an uncommon case of retroperitoneal Castleman syndrome associated with adrenal hyperandrogenism and with interleukin-6 as the possible link in the pathophysiology of both disturbances. Four years after surgical resection of the paraadrenal mass, the patient is free of signs of recurrence of Castleman disease and adrenal hyperandrogenism.
En]KeywordsCastleman disease hyaline vascular type angiofollicular lymph node hyperplasia adrenal hyperandrogenism interleukin-6
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- 4.Azziz R, Bradley EL Jr, Potter HD, Boots LR. Adrenal androgen excess in women: lack of a role for 17-hydroxylase and 1 7,20-lyase dysregulation. J Clin Endocrinol Metab 1 995, 80: 400–Google Scholar
- 7.Mastorakos G, Weber JS, Magiakou MA, Gunn H, Chrousos GP. Hypothalamic-pituitary-adrenal axis activation and stimulation of systemic vasopressin secretion by recombinant interleukin-6 in humans: potential implications for the syndrome of inappropriate vasopressin secretion. J Clin Endocrinol Metab 1994, 79: 934–9.PubMedGoogle Scholar
- 9.Papanicolaou DA, Tsigos C, Oldfield EH, Chrousos GP. Acute glucocorticoid deficiency is associated with plasma elevations of interleukin-6: does the latter participate in the symptomatology of the steroid withdrawal syndrome and adrenal insufficiency? J Clin Endocrinol Metab 1996, 81: 2303–6.PubMedCrossRefGoogle Scholar