Journal of Endocrinological Investigation

, Volume 25, Issue 5, pp 473–476 | Cite as

A case of reversible azoospermia following withdrawal from alcohol consumption

  • E. Vicari
  • A. Arancio
  • V. Giuffrida
  • R. D’Agata
  • A. E. Calogero
Case Report


Chronic alcohol intake is associated with male reproductive function impairment. However, no longitudinal studies have been carried out to determine the recovery of alcohol-related spermatogenetic failure subsequent to moderate periods of abstinence. The present report describes the achievement of a pregnancy 3 months after withdrawal from alcohol consumption in the partner of a patient with azoospermia secondary to heavy alcoholic intake (mean daily alcohol consumption: 90 g). Alcoholism was the putative cause of the infertile condition of this patient because, during alcohol consumption, he first had teratozoospermia characterized by a never reported high percentage of spermatozoa with large heads (associated with a nonmegaloblastic macrocytic anaemia in the blood smear), and subsequently azoospermia.


Alcohol Consumption Azoospermia Semen Quality Sperm Parameter Head Form 
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  1. 1.
    Vicari E., Sidoti G., Moncada M.L., et al. Alterazioni biochimiche, funzionali e citomorfologiche nemaspermiche in lavoratori delle serre. In: Pisani E., Austoni E. (Eds.), Andrologia ’91 — Atti VI Congresso Società Italiana Andrologia (Milano 7-10 luglio 1991). Monduzzi, 1991, pp. 647–653.Google Scholar
  2. 2.
    Tas S., Lauwerys R., Lison D. Occupational hazards for the male reproductive system. Crit. Rev. Toxicol. 1996, 26: 261–307.PubMedCrossRefGoogle Scholar
  3. 3.
    Toppari J., Larsen J.C., Christiansen P., et al. Male reproductive health and environmental xenoestrogens. Environ. Health Perspect. 1996, 104: 741–803.PubMedCentralPubMedGoogle Scholar
  4. 4.
    Van Waeleghem K., De Clercq N., Vermeulen L., Schoonjans F., Comhaire F. Deterioration of sperm quality in young healthy Belgic men. Hum. Reprod. 1996, 11: 325–329.PubMedCrossRefGoogle Scholar
  5. 5.
    Pajarinen J.T., Karhunen P.J., Lalu K., et al. Moderate alcohol consumption and disorders of human spermatogenesis. Alcohol. Clin. Exp. Res. 1996, 20: 332–337.PubMedCrossRefGoogle Scholar
  6. 6.
    Iranmanesh A., Veldhuis J.D., Samojlik E., Rogol A.D., Johnson M.L., Lizarralde G. Alterations in the pulsatile properties of gonadotropin secretion in alcoholic men. J. Androl. 1988, 9: 207–214.PubMedGoogle Scholar
  7. 7.
    Kuller L.H., May S.J., Perper J.A. The relationship between alcohol, liver disease, and testicular pathology. Am. J. Epidemiol. 1978, 108: 192–199.PubMedGoogle Scholar
  8. 8.
    Boiesen P.T., Lindholm J., Hagen C., Bahnsen M., Fabricius-Bjerre N. Histological changes in testicular biopsies from chronic alcoholics with and without liver disease. Acta Pathol. Microbiol. Scand. 1979, 87: 139–142.Google Scholar
  9. 9.
    World Health Organization. WHO laboratory manual for the examination of human semen and semen-cervical mucus interaction, 3rd ed. Cambridge University Press, Cambridge, 1992.Google Scholar
  10. 10.
    Kruger T.F., Menkveld R., Stander F.S., et al. Sperm morphologic features as a prognostic factor in in-vitro fertilization. Fertil. Steril. 1986, 46: 1118–1123.PubMedGoogle Scholar
  11. 11.
    Kucheria K., Saxena R., Mohan, D. Semen analysis in alcohol dependence syndrome. Andrologia 1985, 17: 558–563.PubMedCrossRefGoogle Scholar
  12. 12.
    Nagy F., Pendergrass P.B., Bowen D.C., Yeager J.C. A comparative study of cytological and physiological parameters of semen obtained from alcoholics and non-alcoholics. Alcohol Alcohol. 1986, 21: 17–23.PubMedGoogle Scholar
  13. 13.
    Villalta, J., Ballesca, J.L., Nicolas, J.M., et al. Testicular function in asymptomatic chronic alcoholics: relation to ethanol intake. Alcohol. Clin. Exp. Res. 1997, 21: 128–133.PubMedGoogle Scholar
  14. 14.
    Dunphy B.C., Barratt C.L., Cooke I.D. Male alcohol consumption and fecundity in couples attending an infertility clinic. Andrologia 1991, 23: 219–221.PubMedCrossRefGoogle Scholar
  15. 15.
    Goverde H.J., Dekker H.S., Janssen H.J., Bastiaans B.A., Rolland R., Zielhuis G.A. Semen quality and frequency of smoking and alcohol consumption- an explorative study. Int. J. Fertil. Menopausal Stud. 1995, 40: 135–138.PubMedGoogle Scholar
  16. 16.
    Vine M.F., Setzer R.W. Jr., Everson R.B., Wyrobek, A.J. Human sperm morphometry and smoking, caffeine, and alcohol consumption. Reprod. Toxicol. 1997, 11: 179–184.PubMedCrossRefGoogle Scholar
  17. 17.
    Pajarinen J.T., Karhunen P.J. Spermatogenic arrest and “Sertoli cell-only” syndrome — common alcohol-induced disorders of the human testis. Int. J. Androl. 1994, 17: 292–299.PubMedCrossRefGoogle Scholar
  18. 18.
    Kley H.K., Teschke, R. Alcohol and fertility: sex hormones. Z-Hautkr. 1985, 60: 1017–1025.PubMedGoogle Scholar
  19. 19.
    Schramm, P. Alcohol and fertility- from the andrological point of view. Z. Hautkr. 1985, 60: 1026, 1031-1032, 1037-1039.PubMedGoogle Scholar
  20. 20.
    Pajarinen J.T., Savolainen V.T., Perola, M., Penttila A., Karkunen RT. Glutathione S-transferase-M1 “null” genotype and alcohol-induce disorder of human spermatogenesis. Int. J. Androl. 1996, 19: 155–163.PubMedCrossRefGoogle Scholar
  21. 21.
    Hayashi S., Watanabe J., Kawajiri, K. Genetic polymorphisms in the 5’ flanking region change trascriptional regulation of the human cytochrome P 450 IIEI gene. J. Biochem. 1991, 110: 559–565.PubMedGoogle Scholar
  22. 22.
    Pajarinen J.T., Savolainen V.T., Perola M., Penttila A., Karkunen PJ. Polymorphism in the cytochrome P450 2E1 gene and alcohol-induced disorders of human spermatogenesis. Int. J. Androl. 1996, 19: 314–322.PubMedCrossRefGoogle Scholar
  23. 23.
    Willis B.R., Anderson R.A. Jr., Oswald C., Zaneveld L.J. Ethanol-induced male reproductive tract pathology as a function of ethanol dose and duration of exposure. J. Pharmacol. Exp. Ther. 1983, 225: 470–478.PubMedGoogle Scholar
  24. 24.
    Shirai T., Ikemoto I. Mechanism of alcoholic testicular damage. Nippon Hinyokika Gakkai Zasshi 1992, 83: 305–314.PubMedGoogle Scholar
  25. 25.
    Van Thiel D.H., Gavaler J.S., Sanghyi, A. Recovery of sexual function in abstinent alcoholic men. Gastroenterology 1983, 84: 677–682.PubMedGoogle Scholar
  26. 26.
    Anderson R.A. Jr., Willis B.R., Oswald C. Spontaneous recovery from ethanol-induced male infertility. Alcohol 1985, 2: 479–484.PubMedCrossRefGoogle Scholar
  27. 27.
    Davenport J. Macrocytic anemia. Am. Fam. Physician 1996, 53: 155–162.PubMedGoogle Scholar
  28. 28.
    Peach H.G., Bath N.E., Farish S. Predictive value of MCV for hazardous drinking in the communities. Clin. Lab. Haematol. 1997, 19: 85–87.PubMedCrossRefGoogle Scholar

Copyright information

© Italian Society of Endocrinology (SIE) 2002

Authors and Affiliations

  • E. Vicari
    • 1
  • A. Arancio
    • 1
  • V. Giuffrida
    • 1
  • R. D’Agata
    • 1
  • A. E. Calogero
    • 1
  1. 1.Division of Endocrinology, Andrology and Internal Medicine, Department of Biomedical SciencesUniversity of Catania, Ospedale GaribaldiCataniaItaly

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