Journal of Thermal Analysis and Calorimetry

, Volume 51, Issue 3, pp 1009–1021 | Cite as

Effect of Norfloxacin Complexation with β-Cyclodextrin on the in Vitro Dissolution Behaviour and its Interaction with Mg2+ and Al3+

  • J. J. Torres-Labandeira
  • P. de Labra Piñón
  • B. Pérez-Marcos
  • C. Alvarez-Lorenzo
  • J. L. Vila-Jato
Special Publication of Cyclodextrins and Their Inclusion Complexes


Interaction between norfloxacin and β-cyclodextrin (β-CD) in solution was characterized by immersion calorimetry studies and nuclear magnetic resonance. 1H-NMR studies suggest that the pyperazine group of norfloxacin is the part of the molecule bound inside the β-CD cavity. Solid inclusion complexes of norfloxacin with β-cyclodextrin were prepared by freeze-drying in two different molar ratios, 1:1 and 1:2, and characterized by X-ray diffractometry and differential scanning calorimetry. Drug dissolution rate was improved by inclusion complexation and norfloxacin incompatibility with metal cations (Mg2+, Al3+) was reduced.


β-cyclodextrin differential scanning calorimetry dissolution immersion calorimetry metal cations norfloxacin nuclear magnetic resonance X-ray diffractometry 


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Copyright information

© Akadémiai Kiadó 1998

Authors and Affiliations

  • J. J. Torres-Labandeira
    • 1
  • P. de Labra Piñón
    • 1
  • B. Pérez-Marcos
    • 1
  • C. Alvarez-Lorenzo
    • 1
  • J. L. Vila-Jato
    • 1
  1. 1.Department of Pharmaceutical Technology, Faculty of PharmacyUniversity of Santiago de CompostelaSantiago de CompostelaSpain

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