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Serum leptin and longevity

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Abstract

There are changes in the ability to regulate energy balance and caloric intake with aging. Consequently, we investigated whether human aging modifies the levels of serum leptin, a novel hormone implicated in the regulation of energy balance. We studied 268 Caucasian men and women aged 22–85 years, and divided them into groups with mean ages of 30, 40, 50, 65, 75, 80 and 85 years. Fasting serum leptin concentrations were determined by radioimmunoassay. Subjects aged 65 or older were followed for five years after the blood sampling. There were no statistically significant differences in fasting serum leptin concentrations across different age groups in females (p=0.090). Fasting serum leptin concentrations were also similar in different age groups in males, except that males in the 30-year age group had lower serum leptin levels than males in the 75-year age group (p=0.042). Leptin levels were 2–3 fold higher in females than in males in each age group (p<0.005 except p=0.063 in the 75-year age group). Elderly women, who lived longer, had 47% higher (p<0.05) serum leptin concentrations, and 17% higher (p<0.001) BMI than the women who died within five years of blood sampling. Leptin levels were not statistically different in these women after adjusting for BMI. Thus, aging has no apparent effect on serum leptin levels in women or men, and the gender difference in leptin is present also in the older age groups. Higher leptin concentrations in the females who live longer may reflect a better nutritional status, and a greater adipose tissue mass rather than a primary factor for survival.

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References

  1. Zhang Y., Proenca R., Maffei M., Barone M., Leopold L., Friedman J.M.: Positional cloning of the mouse obese gene and its human homologue. Nature 372: 425–432, 1994.

    Article  CAS  PubMed  Google Scholar 

  2. Campfield L.A., Smith F.J., Guisez Y., Devos R., Burn P.: Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269: 546–549, 1995.

    Article  CAS  PubMed  Google Scholar 

  3. Halaas J.L., Gajiwala K.S., Maffei M., Cohen S.L., Chait B.T., Rabinowitz D., Lallone R.I., Burley S.K., Friedman J.M.: Weight reducing effects of the plasma protein encoded by the obese gene. Science 269: 543–546, 1995.

    Article  CAS  PubMed  Google Scholar 

  4. Pelleymounter M.A., Cullen M.J., Baker M.B., Hecht R., Winters D., Boone T., Collins F.: Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269: 540–543, 1995.

    Article  CAS  PubMed  Google Scholar 

  5. Frederich R.C., Hamann A., Anderson S., Löllmann B., Lowell B.B., Flier J.S.: Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action. Nature Medicine 1: 1311–1314, 1995.

    Article  CAS  PubMed  Google Scholar 

  6. Considine R.V., Sinha M.K., Heiman M.L., Kriauciunas A., Stephens T.W., Nyce M.R., Ohannesian J.P., Marco C.C., McKee L.J., Bauer T.R., Caro J.F.: Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N. Engl. J. Med. 334: 292–295, 1996.

    Article  CAS  PubMed  Google Scholar 

  7. Maffei M., Halaas J., Ravussin E., Pratley R.E., Lee G.H., Zhang Y., Fei H., Kim S., Lallone R., Ranganathan S., Kern P.A., Friedman J.M.: Leptin levels in human and rodent: Measurement of plasma leptin and ob mRNA in obese and weight reduced subjects. Nature Medicine 1: 1155–1161, 1995.

    Article  CAS  PubMed  Google Scholar 

  8. Kolaczynski J.W., Considine R.V., Ohannesian J., Marco C., Opentanova I., Nyce M.R., Myint M., Caro J.F.: Responses of leptin to short-term fasting and refeeding in humans. A link with ketogenesis but not ketones themselves. Diabetes 45: 1511–1515, 1996.

    Article  CAS  PubMed  Google Scholar 

  9. Roberts S.B., Fuss P., Heyman M.B., Evans W.J., Tsay R., Rasmussen H., Fiatarone M., Cortiella J., Dallal G.E., Young V.R.: Control of food intake in older men. JAMA 272: 1601–1606, 1994.

    Article  CAS  PubMed  Google Scholar 

  10. McGandy R.B., Barrows C.H., Spanias A., Meredith A., Stone J.L., Norris A.H.: Nutrient intake and energy expenditure in men of different ages. J. Gerontol. 21: 581–584, 1996.

    Article  Google Scholar 

  11. Munro H.N., Suter P.M., Russel R.M.: Nutritional requirements of the elderly. Annu. Rev. Nutr. 7: 23–49, 1987.

    Article  CAS  PubMed  Google Scholar 

  12. Poehlman E.T.: Regulation of energy expenditure in aging humans. J. Am. Ger. Soc. 41: 552–559, 1996.

    Google Scholar 

  13. Strandberg T.E., Valvanne J., Erkinjuntti T., Sorva A., Tilvis R.S.: Serum lipids, health, and one-year mortality in randomized age cohorts of 75, 80, and 85 years: the Helsinki Ageing Study. Nutr. Metab. Cardiovasc. Dis. 2: 101–105, 1992.

    Google Scholar 

  14. Hakala S-M., Tilvis R.S., Strandberg T.E.: Blood pressure and mortality in a general aged population: a five-year follow-up of the Helsinki Aging Study. Eur. Heart J. 18: 1019–1023, 1997.

    Article  CAS  PubMed  Google Scholar 

  15. Ma Z., Gingerich R.L., Santiago J.V., Klein S., Smith C.H., Landt M.: Radioimmunoassay of leptin in human plasma. Clin. Chem. 42: 942–946, 1996.

    CAS  PubMed  Google Scholar 

  16. Finley P.R., Schifman R.B., Williams R.J., Lichti D.A.: Cholesterol in high-density lipoprotein: use of Mg2+/dextran sulfate in its enzymatic measurement. Clin. Chem. 26: 931–933, 1978.

    Google Scholar 

  17. Siedel J., Hägele E.O., Ziegenhorn J., Wahlefeldt A.W.: Reagent for the enzymatic determination of serum total cholesterol with improved lipolytic efficiency. Clin. Chem. 29: 1075–1080, 1983.

    CAS  PubMed  Google Scholar 

  18. Bergmeier H.U.: Metoden der enzymatischen Analyse. 3. Auflage, Bd II, Verlag Chemie Weinheim, 1974, p. 1878.

    Google Scholar 

  19. Desbuquouis B., Aurbach G.D.: Use of polyethylene glycol to separate free and antibody-bound peptide hormones in radioimmunoassays. J. Clin. Endocr. 33: 732–738, 1971.

    Article  Google Scholar 

  20. Dixon W.J. (Ed.): BMDP. Statistical Software. University of California Press, London, 1988.

    Google Scholar 

  21. Roberts S.B., Nicholson M., Staten M., Dallal G.E., Sawaya A.L., Heyman M.B., Fuss P., Greenberg A.S.: Relationship between circulating leptin and energy expenditure in adult men and women aged 18 years to 81 years. Obes. Res. 5: 459–463, 1997.

    Article  CAS  PubMed  Google Scholar 

  22. Moller N., O’Brien P., Nair K.S.: Disruption of the relationship between fat content and leptin levels with aging in humans. J. Clin. Endocrinol. Metab. 83: 931–934, 1998.

    CAS  PubMed  Google Scholar 

  23. Ostlund R.E., Yang J.W., Klein S., Gingerich R.: Relation between plasma leptin concentration and body fat, gender, diet, age, and metabolic covariates. J. Clin. Endocrinol. Metab. 81: 3909–3913, 1996.

    CAS  PubMed  Google Scholar 

  24. Rönnemaa T., Karonen S-L., Rissanen A., Koskenvuo M., Koivisto V.A.: Relation between plasma leptin levels and measures of body fat in identical twins discordant for obesity. Ann. Intern. Med. 126: 26–31, 1997.

    Article  PubMed  Google Scholar 

  25. Rosenbaum M., Nicolson M., Hirsch J., Heymsfield S.B., Gallagher D., Chu F., Leibel R.: Effects of gender, body composition, and menopause on plasma concentrations of leptin. J. Clin. Endocrinol. Metab. 81: 3424–3427, 1996.

    CAS  PubMed  Google Scholar 

  26. Wabitsch M., Blum W.F., Muche R., Braun M., Hube F., Rascher W., Heinze E., Teller W., Hauner H.: Contribution of androgens to the gender difference in leptin production in obese children and adolescents. J. Clin. Invest. 100: 808–813, 1997.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  27. Corti M-C., Guralnik J.M., Salive M.E., Harris T., Ferrucci L., Glynn R.J., Havlik R.J.: Clarifying the direct relation between total cholesterol levels and death from coronary heart disease in older persons. Ann. Intern. Med. 126: 753–760, 1997.

    Article  CAS  PubMed  Google Scholar 

  28. de Courten M., Zimmet P., Hodge A., Collins V., Nicolson M., Staten M., Dowse G., Alberti K.G.M.M.: Hyperleptinaemia: the missing link in the metabolic syndrome. Diabetic Med. 14: 200–208, 1997.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Medicine, Ward 112, Room 29, Helsinki University Central Hospital, Haartmaninkatu 4, SF-00290, Helsinki, Finland

    H. A. Koistinen M.D., V. A. Koivisto & R. S. Tilvis

  2. Department of Clinical Chemistry, Helsinki University Central Hospital, Helsinki, Finland

    S-L. Karonen

  3. Department of Medicine, Turku University Central Hospital, Turku, Finland

    T. Rönnemaa

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  1. H. A. Koistinen M.D.
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  2. V. A. Koivisto
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  3. S-L. Karonen
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  4. T. Rönnemaa
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  5. R. S. Tilvis
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Koistinen, H.A., Koivisto, V.A., Karonen, SL. et al. Serum leptin and longevity. Aging Clin Exp Res 10, 449–454 (1998). https://doi.org/10.1007/BF03340158

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