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Aging Clinical and Experimental Research

, Volume 9, Issue 1–2, pp 153–158 | Cite as

Uncoupling of changes in skeletal muscle β-adrenergic receptor density and aerobic capacity during the aging process

  • R. P. Farrar
  • K.A Monnin
  • D. E. Fordyce
  • T. J. Walters
Original Article

Abstract

The results of the present study indicate that the density of the β-adrenergic receptors in the skeletal muscle does not decline with age, despite declines in oxidative capacity both in the skeletal muscle and whole body oxygen consumption. When young rats and old rats of equal body weight trained daily at the same duration and speed for 6 months on the treadmill, skeletal muscle of young and old rats reached the same aerobic capacity. The young demonstrated a significant rise in Bmax of the β receptors, while the old rats did not change their density of receptors. When both young and old rats had the contractile activity of their skeletal muscle raised to the same level through chronic tonic electrical stimulation, the aerobic capacity and β receptor density rose to the same levels in the skeletal muscle. Thus, the contraction-dependent pathway in the senescent muscle appears to function normally given a maximal chronic stimulus via electrical stimulation. These data indicate that the relationship between oxidative capacity, β-adrenergic receptor properties, exercise training, and aging does not appear to be readily explicable by a single unifying mechanism, but probably resides in the interaction of age with a differential responsiveness of the β-adrenergic and/or contraction dependent pathway for stimulation of aerobic capacity in the aging skeletal muscle.

Key words

Aerobic capacity aging β-receptors exercise oxidative capacity skeletal muscle 

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References

  1. 1.
    Goodrick C., Ingram D., Reynolds M., Freeman J., Cider N.: Differential effects of intermittent feeding and voluntary running on body weight and life span in adult rats. J. Gerontol. 38: 36–45, 1983.PubMedCrossRefGoogle Scholar
  2. 2.
    Yu B.P., Masoro E.J., McMahan C.A.: Nutritional influences on aging of Fischer 344 rats: I. Physical, metabolic, and longevity characteristics. J. Gerontol. 40: 657–670, 1985.PubMedCrossRefGoogle Scholar
  3. 3.
    Cartee G.D., Farrar R.P.: Muscle respiratory capacity and VO2max in identically trained young and old rats. J. Appl. Physiol. 63: 257–261, 1987.PubMedGoogle Scholar
  4. 4.
    Cartee G.D., Farrar R.P.: Glycogen training induces glycogen sparing during exercise by old rats. J. Appl. Physiol. 64: 259–265, 1988.PubMedGoogle Scholar
  5. 5.
    Farrar R.P., Martin T.P., Ardies C.M.: The interaction of aging and endurance exercise upon the mitochondrial function of skeletal muscle. J. Gerontol. 36: 642–647, 1981.PubMedCrossRefGoogle Scholar
  6. 6.
    Heath G.W., Hagberg J.M., Ehsani A.A., Holloszy J.O.: A physiological comparison of young and older endurance trained adults. J. Appl. Physiol. Respir. Environ. Exercise Physiol. 51: 634–640, 1981.Google Scholar
  7. 7.
    Williams R.S., Caron M.G., Daniel K.: Skeletal muscle beta-adrenergic receptors: variations due to fiber type and training. Am. J. Physiol. 246: E160–E167, 1984.PubMedGoogle Scholar
  8. 8.
    Kraus W.E., Bernard T.S., Williams R.S.: Interactions between sustained activity on beta-adrenergic receptors in regulation of gene expression in skeletal muscles. Am. J. Physiol. 256: C506–C514, 1989.PubMedGoogle Scholar
  9. 9.
    Williams R.S., Salmons S., Newsholme E.A., Kauffman R.E., Mellor J.: Regulation of nuclear and mitochondrial gene expression by contractile activity in skeletal muscle. J. Biol. Chem. 261: 376–380, 1986.PubMedGoogle Scholar
  10. 10.
    Martin W.H., Coggan A.R., Spina R.J., Saffitz J.E.: Effects of fiber type and training on β-adrenoceptor density in human skeletal muscle. Am. J. Physiol. 20: E736–742, 1989.Google Scholar
  11. 11.
    Abrass I.B., Davis J.L., Scarpace P.J.: Isoproternol responsiveness and myocardial β-adrenergic receptors in young and old rats. J. Gerontol. 37: 156–160, 1982.PubMedCrossRefGoogle Scholar
  12. 12.
    Scarpace P.J., Abrass I.B.: Beta-adrenergic agonist-mediated desentization in senescent rats. Mech. Ageing Dev. 35: 255–264, 1986PubMedCrossRefGoogle Scholar
  13. 13.
    Greenberg L.H., Weiss B.: Beta-adrenergic receptors in aged rat brain: reduced number and capacity of pineal gland to develop supersensitivity. Science 201: 61–63, 1978.PubMedCrossRefGoogle Scholar
  14. 14.
    Dax E.M.: Age-related changes in membrane receptor interactions. Endocrinol. Metab. Clin. 16: 947–963, 1987.Google Scholar
  15. 15.
    Hansford R.G., Castro F.: Age-linked changes in the activity of enzymes of the tricarboxylate cycle and lipid oxidation, and of carnitine content, in muscles of the rat. Mech. Ageing Dev. 19: 191–201, 1982.PubMedCrossRefGoogle Scholar
  16. 16.
    Walters T.J., Sweeney H.L., Farrar R.P.: Influence of electrical stimulation on a fast-twitch muscle in aging rats. J. Appl. Physiol. 71: 1921–1928, 1991.PubMedGoogle Scholar
  17. 17.
    Westgaard R.S., Lomo T.: Control of contractile properties within adaptive ranges of patterns of impulse activity in the rat. J. Neurosci. 8: 4415–4426, 1988.PubMedGoogle Scholar
  18. 18.
    Brooks G.A., White T.P.: Determination of metabolic and heart rate responses to rats to treadmill exercise. J. Appl. Physiol. 45: 1009–1015, 1978.PubMedGoogle Scholar
  19. 19.
    Fell R.D., Lizzo F.H., Cervoni P., Crandall D.L.: Effect of contractile activity on rat skeletal muscle beta-adrenoceptor properties. Proc. Soc. Exp. Biol. Med. 180: 527–532, 1985.PubMedCrossRefGoogle Scholar
  20. 20.
    Scatchard G.: The attractions of proteins for small molecules and ions. Ann. N.Y. Acad. Sci. 51: 660–672, 1949.CrossRefGoogle Scholar
  21. 21.
    Bradford M.: A rapid and sensitive method for the quantita-tion of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72: 248–254, 1976.PubMedCrossRefGoogle Scholar
  22. 22.
    Srere P.A.: Citrate synthase. In: Methods in Enzymology. Academic Press, New York, 13: 3–5, 1969.Google Scholar
  23. 23.
    Buckenmeyer P.J., Goldfarb A.H., Partilla J.S., Pineyro M.A., Dax E.M.: Endurance training, not acute exercise, differentially alters β-receptors and cyclase in skeletal fiber types. Am. J. Physiol. 9: E71–77, 1990.Google Scholar
  24. 24.
    Martin W.H., Murphee S.S., Saffitz J.E.: β-adrenergic receptor distribution among fiber types and resistance arterioles ofGoogle Scholar

Copyright information

© Springer Internal Publishing Switzerland 1997

Authors and Affiliations

  • R. P. Farrar
    • 1
  • K.A Monnin
    • 1
  • D. E. Fordyce
    • 1
  • T. J. Walters
    • 1
  1. 1.Dept. of KinesiologyThe University of Texas at AustinAustinUSA

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