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Aging Clinical and Experimental Research

, Volume 9, Issue 6, pp 391–403 | Cite as

Alterations in β-adrenoceptor mechanisms in the aging heart. Relationship with heart failure

  • N. Ferrara
  • K. Davia
  • P. Abete
  • F. Rengo
  • S. E. Harding
Review Article

Abstract

In chronic heart failure substantial and characteristic changes occur in the function of the adrenergic nervous system. Studies in isolated left ventricular muscle and in single cardiomyocytes from experimental models of aging and, recently, from humans show an age-related reduced contractile response to β-adrenoceptor stimulation. “β-adrenoceptor desensitization” is thought to be a general and common mechanism to explain the age- and heart failure-related decrease in β-adrenoceptor response. The aim of this review is to compare alterations in β-adrenoceptor mechanisms in physiological cardiovascular aging and chronic heart failure. From an analysis of the overall data on the role of aging in β-adrenoceptor regulation in human and animal hearts, it is possible to conclude that the reduced response to β-agonists is common to all species and all cardiac tissues. Moreover, the age-related changes are limited to β-adrenoceptor-G-protein (s)-adenylyl cyclase system abnormalities, while the type and level of abnormalities change with species and tissues. The modifications shown in the aging heart are not very different from some observed in heart failure. In particular, both in aged and failing hearts we may see that the decrease in β-adrenoceptor responsiveness is related to changes in G-protein function.

Key words

Aging heart failure β-adrenergic receptor β-adrenoceptor desensitization G-protein 

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Copyright information

© Springer Internal Publishing Switzerland 1997

Authors and Affiliations

  • N. Ferrara
    • 1
    • 3
  • K. Davia
    • 2
  • P. Abete
    • 1
  • F. Rengo
    • 1
  • S. E. Harding
    • 2
  1. 1.Institute of Internal Medicine, Cardiology and Cardiovascular Surgery“Federico II” UniversityNapoliItaly
  2. 2.Department of Cardiac MedicineNational Heart and Lung Institute, Imperial CollegeLondonUK
  3. 3.“Salvatore Maugeri” Foundation, IRCCSRehabilitation Institute of TeleseBeneventoItaly

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