Abstract
Background and aims: Vitamin D deficiency is a well-known risk for hip fracture, and vitamin D insufficiency is so frequent in the elderly that population-wide preventive intervention would be useful. The objective of the study was to evaluate the efficacy of vitamin D bolus on hip fracture incidence in elderly women. Methods: All women aged >65 years registered at Health District 20 of the Regione Veneto, Italy, were eligible for this quasi-experimental, prospective community intervention study. A vial containing 400,000 IU vitamin D{in2} (Ostelin 800, Teofarma, Italy) was offered for oral administration to all women in the winters of 2000–2001 and 2001–2002. The only exclusion criteria for treatment were age and gender, and the control group included women who did not participate in the Health District initiative. Analysis of hip fracture incidence was carried out for 4 years, from 1999 to 2002. Patients with incident hip fracture were identified as soon as they were admitted to one of the 3 hospitals of the health district and interviewed regarding their participation in the vitamin D preventive intervention program. In 120 of the women (age range 68–90 years), serum concentrations of 25-OH vitamin D were measured from October to June, both before and 1 and 4 months after vitamin D administration. Results: 23,325 and 24,747 women received the vitamin D bolus during winters 2000–2001 and 2001–2002 respectively, i.e. 45–47% of eligible women. The proportion of women who accepted the bolus declined with advancing age, from 50–55% in women aged 60–70 years to 22–26% in those aged >90 years. The two-year intervention on the community decreased the incidence of fracture by 10% (p=0.050) in comparison with the previous two years. The age-adjusted risk reduction (RR) of hip fracture during 2001 and 2002 in women who had received vitamin D, with respect to women who had not, decreased by 17% (p=0.056) and 25% (p=0.005) respectively. The RR was considerably greater and statistically significant over both 2001 and 2002 in the cohort aged >75 years. 25-OH vitamin D concentrations, in the subset of women in whom it was measured, rose significantly (p<0.0001) by 9 ng/ml over 4 months after administration. Conclusion: Despite several obvious limitations due to its nature, this study sufficiently documents that yearly vitamin D bolus supplements, given as primary prevention to elderly Caucasian women, may decrease the incidence of hip fracture. For its probable safety and excellent feasibility and cost-effectiveness, this primary intervention has a great potential for generalisability.
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References
Parfitt AM, Gallagher JC, Heaney RP, Johnston CC, Neer R, Whedon GD. Vitamin D and bone health in the elderly. Am J Clin Nutr 1982; 36: 805–6.
Lips P, Netelenbos JC, Jongen MJ, et al. Histomorphometric profile and vitamin D status in patients with hip fracture. Metab Bone Dis Relat Res 1982; 4: 85–93.
Chrischilles EA, Butler CD. Davis CS. Wallace RB. A model of lifetime osteoporosis impact. Arch Intern Med 1991; 151: 2026–32.
Thomas MK, Lloyd-Jones MD, Thadhani RI, et al. Hypovitaminosis D in medical inpatients. N Engl J Med 1998; 338: 777–83.
Lips P, Duong T, Oleksik A, et al. A global study of vitamin D status and parathyroid function in postmenopausal women with osteoporosis: baseline data from the Multiple Outcomes of Raloxifene valuation clinical trial. J Clin Endocrinol Metab 2001; 86: 1212–21.
van der Wielen RP, Lowik MRH, van den Berg H, et al. Serum vitamin D concentrations among elderly people in Europe. Lancet 1995; 346: 207–10.
Isaia G, Giorgino R, Rini GB, Bevilacqua M, Maugeri D, Adami S. Prevalence of hypovitaminosis D in elderly women in Italy: clinical consequences and risk factors. Osteoporos Int 2003; 14: 577–82.
Barrett-Connor E, Gore R, Browner WS, Cummings SR. Prevention of osteoporotic hip fracture: global versus high-risk strategies. Osteoporos Int 1998; 8: S2–7.
Adami S, Braga V, Zamboni M, et al. Relationship between lipids and bone mass in 2 cohorts of healthy women and men. Calcif Tissue Int 2004; 74: 136–42.
Chapuy MC, Arlot ME, Duboeuf F, et al. Vitamin D and calcium to prevent hip fractures in elderly women. N Engl J Med 1992; 327: 1637–42.
Dawson-Hughes B, Harris SS, Krall EA, Dallai GE. Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. N Engl J Med 1997; 337: 670–6.
Heikinheimo RJ, Inkovaara JA, Harju EJ, et al. Annual injection of vitamin D and fractures of aged bones. Calcif Tissue Int 1992; 51: 105–10.
Lips P, Graafmans WC, Ooms ME, Brezemer PD, Bouter LM. Vitamin D supplementation and fracture incidence in elderly persons. A randomized, placebo controlled clinical trial. Ann Intern Med 1996; 124: 400–6.
Dawson-Hughes B, Dallai GE, Krall EA, Harris S, Sokoll LJ, Falconer G. The effect of vitamin D supplementation on wintertime and overall bone loss in healthy postmenopausal women. Ann Intern Med 1991; 115: 505–12.
Trivedi DP, Doll R, Khau KT. Effect of four monthly vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial. BMJ 2003; 326: 469–72.
Bischoff HA, Stahelin HB, Dick W, et al. Effects of vitamin D and calcium supplementation on falls: a randomized controlled trial. J Bone Miner Res 2003; 18: 343–51.
Garland CF, Garland FC, Gorham ED. Calcium and vitamin D. their potential roles in colon and breast cancer prevention. Ann NY Acad Sci 1999; 889: 107–19.
Scraag R, Jackson R, Holdaway IM, Lim T, Beaglehole R. Myocardial infarction is inversely associated with plasma 25-hydroxyvitamin D3 levels: a community based study. Int J Epidemiol 1990; 19: 559–62.
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Rossini, M., Alberti, V., Flor, L. et al. Effect of oral vitamin D2 yearly bolus on hip fracture risk in elderly women: a community primary prevention study. Aging Clin Exp Res 16, 432–436 (2004). https://doi.org/10.1007/BF03327397
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DOI: https://doi.org/10.1007/BF03327397