Chinese Science Bulletin

, Volume 48, Issue 7, pp 615–619 | Cite as

Nuclear migration: Endless efforts toward unraveling its molecular apparatus

  • Heng Liu
  • Guangqin Guo
  • Yuke He
  • Guochang Zheng


Nuclear migration is a non-random movement of nucleus toward specific site in the cell in many eukaryotes and essential to normal cellular activities of growth, division and development. It is shown that cytoskeleton and its associated proteins are involved in this process, which have been best analyzed in yeast and filamentous fungi but just started in higher plants. The purpose of this review is to comment the advances in this field.


nuclear migration cytoskeleton motor 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Bloom, K., Nuclear migration: cortical anchors for cytoplasmic dynein, Curr. Biol., 2001, 11: R326–R329.CrossRefGoogle Scholar
  2. 2.
    Raff, J. W., Nuclear migration: The missing (L)UNC? Curr. Biol., 1999, 9: R708–R710.CrossRefGoogle Scholar
  3. 3.
    Hartwell, L. H., Culotti, J., Pringle, J. R. et al., Genetic control of the cell division cycle in yeast, Science, 1974, 183: 46–51.CrossRefGoogle Scholar
  4. 4.
    Morris, N. R., Nuclear migration: From fungi to the mammalian brain, J. Cell Biol., 2000, 148: 1097–1101.CrossRefGoogle Scholar
  5. 5.
    Xiang, X., Morris, N. R., Hyphal tip growth and nuclear migration, Curr. Opin. Micro., 1999, 2: 636–640.CrossRefGoogle Scholar
  6. 6.
    Suelmann, R., Fischer, R., Nuclear migration in fungi—different motors at work, Res. Microbiol., 2000, 151: 247–254.CrossRefGoogle Scholar
  7. 7.
    Chytilova, E., Macas, J., Galbraith, D. W., Green fluorescent protein targeted to the nucleus, a transgenic phenotype useful for studies in plant biology, Annals of Botany, 1999, 83: 645–654.CrossRefGoogle Scholar
  8. 8.
    Gates, R. R., Pollen formation in Oenothera gigas, Ann. Bot., 1911, 25: 909–940.Google Scholar
  9. 9.
    Bahl, J. R., Tyagi, B. R., Cytomixis in pollen mother cells of Paoaver dubium L, Cytologia, 1988, 53: 771–775.CrossRefGoogle Scholar
  10. 10.
    Feijo, J. A., Pais, M. S., Cytomixis in meiosis during the microsporogenesis of Ophrys lutea: an ultrastructural study, Caryologia, 1989, 42: 37–48.Google Scholar
  11. 11.
    Zalokar, M., Erk, I., Division and migration of nuclei during early embrogenesis of Drosophila melanogaster, J. Microbiol. Cell, 1976, 25: 97–106.Google Scholar
  12. 12.
    Baker, J., Theurkauf, W. E., Schubiger, G., Dynamic changes in microtubule configuration correlate with nuclear migration in the preblastoderm Drosophila embryo, J. Cell Biol., 1993, 122: 113–121.CrossRefGoogle Scholar
  13. 13.
    Reinsch, S., Gonczy, P., Mechanisms of nuclear positioning, J. Cell Sci., 1998, 111: 2283–2295.Google Scholar
  14. 14.
    Lambert de Rouvroit, C., Goffmet, A. M., Neuronal migration, Mec. Dev., 2001, 105: 47–56.CrossRefGoogle Scholar
  15. 15.
    Suelmann, R., Sievers, N., Fischer, R., Nuclear traffic in fungal hyphae: In vivo study of nuclear migration and positioning in Aspergillus nidulans, Mol. Microbiol., 1997, 25: 757–769.CrossRefGoogle Scholar
  16. 16.
    Schoenwolf, G. C., Smith, J. L., Mechanisms of neurulation: traditional viewpoint and recent advances, Development, 1990, 109: 243–270.Google Scholar
  17. 17.
    Bloom, K., It’s a kar9ochore to capture microtubules, Nat. Cell Biol., 2000, 2: E96–E98.CrossRefGoogle Scholar
  18. 18.
    Roshchin, A. M., Migration of nuclei in diatom vegetative cells, Zh. Obshch. Biol., 1974, 35: 429–439.Google Scholar
  19. 19.
    Guo, G. Q., Zheng, G. C., Application of the green fluorescent protein in studies on molecular biology of living cell, World Sci-tech. R&D (in Chinese), 1998, 20: 70–75.Google Scholar
  20. 20.
    Suelmann, R., Fischer, R., Nuclear migration in fungi—different motors at work, Res. Microbiol., 2000, 151: 247–254.CrossRefGoogle Scholar
  21. 21.
    Segal, M., Bloom, K., Control of spindle polarity and orientation in Saccharomyces cerevisiae, Trends Cell Biol., 2001, 11: 160–166.CrossRefGoogle Scholar
  22. 22.
    Morris, N. R., Xiang, X., Beckwith, S. M., Nuclear migration advances in fungi, Trends Cell Biol., 1995, 5: 278–282.CrossRefGoogle Scholar
  23. 23.
    Plamann, M., Minke, P. F., Tinsley, J. H. et al., Cytoplasmic dynein and actin-related protein Arp 1 are required for normal nuclear distribution in filamentous fungi, J. Cell Biol., 1994, 127: 139–149.CrossRefGoogle Scholar
  24. 24.
    McConnell, S. J., Yaje, M. P., Intermediate filament formation by a yeast protein essential for organelle inheritance, Science, 1993, 260: 687–689.CrossRefGoogle Scholar
  25. 25.
    Yang, J., Yu, C. H., Wang, X. Y. et al., Ultrastructural observation on the intra-and intercellular microtrabecular network of the pollen mother cells in Onion (Allium cepa), Acta. Botanica Sinica, 2001, 43: 331–338.Google Scholar
  26. 26.
    Pan, Y. F., Wang, X. Y., Zheng, G. C., The arrangement of microtrabecular network during chromatin migration process and immunolocalization of actin and myosin in pollen mother cells of David Lily, Caryologia, 2002, 55: 217–227.CrossRefGoogle Scholar
  27. 27.
    Wang, X. Y., Effects of cytochalasin B on the development of pollen mother cells of Secale Cereale L., Acta Boil. Exp. (in Chinese), 1988, 21: 11–21.Google Scholar
  28. 28.
    Wang, Y. X., Nie, X. W., Zheng, G. C., The effects of cytochalasin B on chromatin movement through cell wall, Chin. Bull. Bot. (in Chinese), 1984, 2: 39–41.Google Scholar
  29. 29.
    Zheng, G. C., Wang, Y. X., Nie, X. W. et al., Studies on cytomixis in pollen mother cells of higher plants, J. Lanzhou Univ., Natural Sciences (in Chinese), 1999, 35: 94–102.Google Scholar
  30. 30.
    Yuan, M., Fu, Y., Wang, F. et al., Fertilization in Torenia fournieri: actin organization and nuclear behavior in the central cell and primary endosperm, Science in China, Ser. C, 2002, 45: 211–224.CrossRefGoogle Scholar
  31. 31.
    Fischer, R., Nuclear movement in filamentous fungi, FEMS Microbiol. Reviews, 1999, 23: 39–68.CrossRefGoogle Scholar
  32. 32.
    Morris, S. M., Albrecht, U., Reiner, O. et al., The lissencephaly gene product Lis1, a protein involved in neuronal migration, interacts with a nuclear movement protein, NudC, Curr. Biol., 1998, 8: 603–606.CrossRefGoogle Scholar
  33. 33.
    Dobyns, W. B., Truwit, C. L., Lissencephaly and other malformations of cortical development: 1995, Mpdcte, Neuropediatrics, 1995, 26: 132–147.CrossRefGoogle Scholar
  34. 34.
    Walsh, C. A., Goffinet, A. M., Potential mechanisms of mutations that affect neuronal migration in man and mouse, Curr. Opin. Genet. Dev., 2000, 10: 270–274.CrossRefGoogle Scholar
  35. 35.
    Morris, N. R., Efimov, V. P., Xiang, X., Nuclear migration, nucleokinesis and lissencephaly, Trends Cell Biol., 1998, 8: 467–470.CrossRefGoogle Scholar
  36. 36.
    Moscatelli, A., Del Casino, C., Lozzi, L. et al., High molecular weight polypeptides related to dynein heavy chains in Nicotiana tabacum pollen tubes, J. Cell Sci., 1995, 108: 1117–1125.Google Scholar
  37. 37.
    Reddy, A. S., Day, I. S., Analysis of the myosins encoded in the recently completed Arabidopsis thaliana genome sequence, Genome Biology, 2001, 2: research0024.1–0024.17.Google Scholar
  38. 38.
    Beach, D. L., Salmon, E. D., Bloom, K., Localization and anchoring of mRNA in budding yeast, Current Biology, 1999, 9: 569–578.CrossRefGoogle Scholar
  39. 39.
    Im, K. H., Cosgrove, D. J., Jones, A. M., Subcellular localization of expansin mRNA in xylem cells, Plant Physiol, 2000, 123: 463–470.CrossRefGoogle Scholar

Copyright information

© Science in China Press 2003

Authors and Affiliations

  • Heng Liu
    • 1
  • Guangqin Guo
    • 1
  • Yuke He
    • 2
  • Guochang Zheng
    • 1
  1. 1.Institute of Cell Biology, School of Life SciencesLanzhou UniversityLanzhouChina
  2. 2.Institute of Plant Physiology and EcologyShanghai Academy of Life Sciences, Chinese Academy of SciencesShanghaiChina

Personalised recommendations