Aging Clinical and Experimental Research

, Volume 20, Issue 6, pp 494–495 | Cite as

Management of very elderly hypertensives: the HYVET study

  • Giuseppe Mancia
  • Guido Grassi


Antihypertensive treatment clinical trials dementia elderly 


  1. 1.
    Staessen JA, Gasowski J, Wang JG et al. Risks of untreated and treated isolated systolic hypertension in the elderly: meta-analysis of outcome trials. Lancet 2000; 355: 865–72.PubMedCrossRefGoogle Scholar
  2. 2.
    Gueyffier F, Bulpitt C, Boissel JP et al. Antihypertensive drugs in very old people: a subgroup meta-analysis of randomised controlled trials. INDANA Group. Lancet 1999; 353: 793–6.PubMedCrossRefGoogle Scholar
  3. 3.
    Beckett NS, Peters R, Fletcher AE et al. Treatment of hypertension in patients 80 years of age or older. N Engl J Med 2008; 358: 1887–98.PubMedCrossRefGoogle Scholar
  4. 4.
    Manda G, De Backer G, Dominiczak A et al. 2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens 2007; 25: 1105–87.CrossRefGoogle Scholar
  5. 5.
    Mancia G, Di Rienzo M, Grassi G, Parati G. Blood pressure variability and reflex control in the elderly. Aging Clin Exp Res 1995; 7: 3–9.CrossRefGoogle Scholar
  6. 6.
    Skoog I, Lernfelt B, Landahl S et al. 15-year longitudinal study of blood pressure and dementia. Lancet 1996; 347: 1141–5.PubMedCrossRefGoogle Scholar
  7. 7.
    Kähönen-Väre M, Brunni-Hakala S, Lindroos M, Pitkala K, Strandberg T, Tilvis R. Left ventricular hypertrophy and blood pressure as predictors of cognitive decline in old age. Aging Clin Exp Res 2004; 16: 147–52.PubMedCrossRefGoogle Scholar
  8. 8.
    Yamamoto Y, Akiguchi I, Oiwa K, Hayashi M, Kasai T, Ozasa K. Twenty-four-hour blood pressure and MRI as predictive factors for different outcomes in patients with lacunar infarct. Stroke 2002; 33: 297–305.PubMedGoogle Scholar
  9. 9.
    Peters R, Beckett N, Forette F et al. Incident dementia and blood pressure lowering in the Hypertension in the Very Elderly Trial cognitive function assessment (HYVET-COG): a double-blind, placebo controlled trial. Lancet Neurol 2008; 7: 683–9.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Internal Publishing Switzerland 2008

Authors and Affiliations

  1. 1.Clinica Medica, Dipartimento di Medicina Clinica e PrevenzioneUniversità Milano-Bicocca, Ospedale San Gerardo, Ospedale S. Gerardo dei TintoriMonza (MI)Italy

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