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Aging Clinical and Experimental Research

, Volume 19, Issue 6, pp 472–477 | Cite as

Long-term 1,25(OH)2 vitamin D therapy increases bone mineral density in osteopenic women. Comparison with the effect of plain vitamin D

  • Ivana Zofkova
  • Martin Hill
Original Articles
  • 54 Downloads

Abstract

Backgroud and aims: Although the bone protective effect of vitamin D has been studied intensively, the usefulness of 1,25(OH)2D3 in treating osteoporosis is still questionable. The aim of the present prospective study was to evaluate the effect of a standard pharmacological dose of 1,25(OH)2D3 in post-menopausal unsubstituted women. Methods: Our study group comprised 52 post-menopausal women with low normal or osteopenic values of bone mineral density (BMD). Thirty-two of them were treated with 1,25(OH)2D3 for 3 years. In parallel, another group of women was treated with cholecalciferol (n=20). Vitamin D adequacy before administration of 1,25(OH)2D3 and compliance with treatment were checked by serum PTH levels, which were assessed at the start and three times in the course of treatment. Results: Increase in BMD at the spine at the end of the 1st, 2nd and 3rd years of treatment with 1,25(OH)2D3 (expressed as a percentage of the value before treatment) was higher, but did not significantly differ from the effect of plain vitamin D. A significant increase in BMD at the hip at the end of the 3rd (but not the 1st and 2nd) year of treatment with 1,25(OH)2D3 was found (p<0.05, compared with the effect of plain vitamin D). The protective effect of cholecalciferol was found only on spine but not hip BMD. Conclusion: The study supports the hypothesis that long-term administration of 1,25(OH)2D3 is effective in treating low bone mass in post-menopausal women.

Keywords

Bone density 1,25-dihydroxyvitamin D3 cholecalciferol 

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Copyright information

© Springer Internal Publishing Switzerland 2007

Authors and Affiliations

  1. 1.Institute of EndocrinologyPragueCzech Republic

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