Aging Clinical and Experimental Research

, Volume 19, Issue 5, pp 344–348 | Cite as

Cognitive impairment: classification and open issues

  • Cristina Basso
  • Federica Limongi
  • Paola Siviero
  • Giovanna Romanato
  • Marianna Noale
  • Stefania Maggi
  • Leontino Battistin
  • Gaetano Crepaldi
Mini Review


Several clinically-defined cognitive impairment syndromes, with differing diagnostic criteria and nomenclature, have been proposed to describe nondisabling symptomatic cognitive deficits. Incidence and prevalence rates vary as a result of different diagnostic criteria and sampling procedures across studies. The incidence rates of cognitive impairment increase with age; but no consistent data have been reported on the association with family history, age, sex, education, Apo E4 genotype, depression, and other traditional risk factors for dementia. Severalstudies have suggested that most patients with cognitive impairment clinically defined will progress to Alzheimer Disease (AD), but rates of conversion vary widely among studies. This review summarizes existing definitions and related epidemiological data.


Cognitive impairment dementia 


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Copyright information

© Springer Internal Publishing Switzerland 2007

Authors and Affiliations

  • Cristina Basso
    • 1
  • Federica Limongi
    • 1
  • Paola Siviero
    • 1
  • Giovanna Romanato
    • 1
  • Marianna Noale
    • 1
  • Stefania Maggi
    • 1
  • Leontino Battistin
    • 2
  • Gaetano Crepaldi
    • 1
  1. 1.CNR Aging Section, Institute of NeurosciencePadovaItaly
  2. 2.IRCCS San Camillo, Lido di VeneziaItaly

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