Is late- life caloric restriction beneficial?
- 8 Downloads
Caloric restriction initiated in young mice and rats results in increases in mean and median life span. When caloric restriction is implemented in older animals, an increase in life span is still observed; however, the magnitude of the increase is not as great as that observed in animals calorie restricted since they were young. Here we report the results of a pilot study in which caloric restriction was initiated in mature, older rats. Survival rates and terminal pathology were characterized and compared between a cohort of 17 continually ad libitum fed Long Evans rats and a cohort of 18 Long Evans rats, which were gradually introduced to 33% restriction in diet consumption at 18 months of age. No difference in the median life span was observed between the two groups. The data suggest there may be a level of maturity, or a stage in the aging process, after which caloric restriction no longer increases longevity. (Aging Clin. Exp. Res. 7: 136 -139, 1995 )
KeywordsAging caloric restriction mortality rats
Unable to display preview. Download preview PDF.
- 8.Finch C.E.: Longevity, Senescence and the Genome. The University of Chicago Press, Chicago, 1990, p. 510.Google Scholar
- 9.Vallejo E.A.: La dieta de hambre a dias alternos en la alimentacion de los viejos. La Presna Medica Argentina 44: 119–120, 1957.Google Scholar
- 10.Cornoni-Huntley J.C. Harris T.B., Everett D.F., Albanes D., Micozzi M.S., Miles T.P., Feldman J.J.: An overview of body weight of older persons, including the impact of mortality: the National Health and Nutrition Examination Survey. I. Epidemiologic follow-up study. J. Clin. Epidemiol. 44: 743–753, 1991.PubMedCrossRefGoogle Scholar
- 11.National Academy of Sciences: Nutrient Requirements of Laboratory Animals. Washington, D.C., 1978, pp. 7-37.Google Scholar
- 12.Hoffman H.J.: Survival distributions for selected laboratory rat strains and stocks. In: Gibson D.C., Adelman R.L., Finch C. (Eds.), Development of the rodent as a model system of aging. Book II. DHEW Pub. No. (NIH) 76-161, 1979.Google Scholar
- 13.Charles River Technical Bulletin, 1984, 1:4.Google Scholar
- 14.Bronson R.T.: Rate of occurence of lesions in 20 inbred and hybrid genotypes of rats and mice sacrificed at 6 month intervals during the first years of life. In: Harrison D.E. (Ed.), Genetic effects of aging. II. The Telford Press, Inc., New Jersey, 1990, pp. 279–358.Google Scholar