Aging Clinical and Experimental Research

, Volume 6, Issue 6, pp 451–458 | Cite as

Sleep in non-institutionalized Alzheimer’s disease patients

  • Sonia Ancoli-Israel
  • M. R. Klauber
  • J. C. Gillin
  • S. S. Campbell
  • C. R. Hofstetter
Original Article


The sleep of Alzheimer’s disease (AD) patients is often disturbed by medications, depression, circadian rhythm changes and sleep disorders. Institutionalization is often precipitated by the effect of the patient’s sleep and wakefulness on the caregiuer. We examined reports of sleep disturbance in mild AD patients. The study cohort consisted of 246 AD patients and 94 controls. Self-reports of sleep disturbance in mild AD patients were examined as was the relationship of sleep and medication use. Results were compared to those of normal controls, and the patients’ responses to the reports of their caregiuers. Dementia was assessed with the Mini Mental Status Exam, the Blessed Dementia Scale, the Mattis Dementia Rating Scale, and the Pfeiffer Outpatient Disability Test. The more demented the patients, the more time they spent in bed, the more fragmented their sleep, and the more naps they took. Caregiuers reports of increased wandering at night and more aggressive behavior during the day were associated with increased use of sedative-hypnotics and with going to bed early. Lengthy sleep was associated with disruptive behavior. We conclude that increased sleep may be associated with dementia and with more disruptive behavior. (Aging Clin. Exp. Res. 6: 451-458, 1994)


Alzheimer’s disease caregivers hypnotics napping sleep 


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Copyright information

© Springer Internal Publishing Switzerland 1994

Authors and Affiliations

  • Sonia Ancoli-Israel
    • 1
    • 2
  • M. R. Klauber
    • 2
    • 3
    • 4
  • J. C. Gillin
    • 1
  • S. S. Campbell
    • 5
  • C. R. Hofstetter
    • 4
    • 6
  1. 1.Department of PsychiatryUniversity of California San Diego and Veterans Affairs Medical CenterSan DiegoUSA
  2. 2.Sam and Rose Stein Institute for Research on AgingUSA
  3. 3.Department of Family and Preventive MedicineUniversity of California San DiegoUSA
  4. 4.Alzheimer’s Disease Research CenterUniversity of California San DiegoUSA
  5. 5.Department of PsychiatryCornell University Medical CollegeUSA
  6. 6.Department of Political ScienceSan Diego State UniversitySan DiegoUSA

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