PharmacoEconomics Italian Research Articles

, Volume 3, Issue 2, pp 105–114 | Cite as

Analisi costi-efficacia del trattamento con n-3 PUFA nel post-infarto miocardico: i risultati dello studio GISSI-Prevenzione

  • Maria Grazia Franzosi
  • M. Brunetti
  • R. Marchioli
  • R. M. Marfisi
  • G. Tognoni
  • F. Valagussa
  • Ricercatori del GISSI-Prevenzione

Cost-effectiveness analysis of n-3 polyunsaturated fatty acids (PUFA) after myocardial infarction



To estimate the cost-effectiveness of treatment with n-3 polyunsaturated fatty acids (PUFA) for secondary prevention after myocardial infarction (MI).

Design and setting

The cost-effectiveness analysis of n-3 PUFA treatment after MI was based on morbidity and mortality data and the use of resources obtained prospectively during the 3.5 year follow-up period of the Gruppo Italiano per lo Studio della Sopravvivenza nell’Infarto (GISSI)-Prevenzione study. The cost-effectiveness analysis took into account the incremental number of life-years gained and the incremental costs for hospital admissions, diagnostic tests and drugs, applying a 5% discount rate. The value for money of n-3 PUFA treatment was assessed using the cost-effectiveness ratio and the number needed to treat (NNT) approach.


Third-party payer.

Main outcome measures and results

The incremental cost-effectiveness ratio for n-3 PUFA in the basecase scenario was 24 603 euro (EUR, 1999 values) per life-year gained (95% confidence interval: 22 646 to 26 930). Sensitivity analysis included the analysis of extremes, producing estimates varying from EUR15 721 to EUR52 524 per life-year gained. 172 patients would need to be treated per year with n-3 PUFA, at an annual cost of EUR68 000, in order to save 1 patient. This is comparable with the NNT value, and associated annual cost for simvastatin, but less costly than that for pravastatin.


The cost-effectiveness of long term treatment with n-3 PUFA is comparable with other drugs recently introduced in the routine care of secondary prevention after MI. Since the clinical benefit provided by n-3 PUFA is additive, this therapy should be added to the established routine practice, with additive costs.


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Copyright information

© Adis International Limited 2001

Authors and Affiliations

  • Maria Grazia Franzosi
    • 1
  • M. Brunetti
    • 2
  • R. Marchioli
    • 3
  • R. M. Marfisi
    • 3
  • G. Tognoni
    • 1
  • F. Valagussa
    • 4
  • Ricercatori del GISSI-Prevenzione
  1. 1.Dipartimento di Ricerca CardiovascolareIstituto di Ricerche Farmacologiche “Mario Negri”MilanoItalia
  2. 2.Laboratorio per la Ricerca sui Servizi SanitariIstituto di Ricerche Farmacologiche “Mario Negri”MilanoItalia
  3. 3.Dipartimento di Epidemiologia e Farmacologia clinicaConsorzio Mario Negri Sud, S. Maria ImbaroMilanoItalia
  4. 4.Dipartimento di CardiologiaOspedale San GerardoMonzaItalia

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