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12.25 Aortic Stiffness: a Reversible Marker of Cardiovascular Risk in Primary Hyperparathyroidism?

  • G. Pucci
  • M.R. Mannarino
  • N. Avenia
  • M. Monacelli
  • G. Fabbriciani
  • M. Pirro
  • A.M. Scarponi
  • E. Mannarino
  • G. Schillaci
Contributions from International Congress Vessels and Endothelium
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12.25 Aortic Stiffness: a Reversible Marker of Cardiovascular Risk in Primary Hyperparathyroidism?

Introduction. Patients with primary hyperparathyroidism (PHPT) are at increased risk of cardiovascular death. We investigated whether aortic stiffness, an early marker of arteriosclerosis (Study A) is increased in PHPT and (Study B) improves after parathyroidectomy.

Results. Study A: 19 patients with PHPT (age 57±11 years, BP 149/89 mmHg) and 38age-, sex- and blood pressure-matched control subjects underwent aortic pulse wave velocity (PWV) determination (tonometry). Aortic PWV was significantly higher among PHTP patients(11.3±2 vs 9.7±2 m/s, p<0.01). Study B: 11 of the PHTP patients were re-examined 4 weeks after surgical parathyroidectomy. As expected, surgery was accompanied by a reduction in serum calcium (from 11.4±1 to 8.9±1 mg/dL, p<0.001) and parathyroid hormone (from 415±472 to 31±27 pg/mL, p<0.001). As displayed in figure, aortic PWV decreased after surgery (from 10.6±2 to 9.2±2 m/s, p=0.004), also after adjustment for changes in blood pressure.

Conclusions. Primary hyperparathyroidism is associated with increased aortic stiffness, which improves after parathyroidectomy. We demonstrate that aortic stiffness may improve upon removal of hyperparathyroidic stimuli.

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© Adis Data Information BV 2008

Authors and Affiliations

  • G. Pucci
    • 1
  • M.R. Mannarino
    • 1
  • N. Avenia
    • 1
  • M. Monacelli
    • 1
  • G. Fabbriciani
    • 1
  • M. Pirro
    • 1
  • A.M. Scarponi
    • 1
  • E. Mannarino
    • 1
  • G. Schillaci
    • 1
  1. 1.Medicina Interna, Angiologia e Malattie da ArteriosclerosiUniversità di PerugiaPerugiaItaly

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