Abstract
AIM: To compare the clinical and radiographic success rates of two vital pulpotomy agents: formocresol (FC) and Ankaferd Blood Stopper® (ABS), in primary molars during a 12-month follow-up period. STUDY DESIGN: A randomised, single-blind study design was used in a sample of 30 healthy 6–9 year old children with 60 carious primary molars without clinical or radiographic evidence of pulp degeneration. METHODS: The pulpotomy agents were assigned as follows: Group 1 was 1:5 diluted Buckley’s formocresol (FC) and Group 2 was ABS. Clinical and radiographic follow-up at 3, 6, and 12 months used the following criteria: pain, swelling, sinus tract, mobility, internal root resorption, and furcation and/or periapical bone destruction. STATISTICS: The data were analysed using Chi-square tests. RESULTS: The clinical and radiographic evaluation at 3 months revealed total success rates of 100% in the FC and ABS groups. Success rates in FC and ABS groups at 6 months were 96.7% and 93.3% respectively. At the 12-month follow-ups, the total success rates in the FC, and ABS groups were 89.3% and 85.7%, respectively. When the groups were compared according to the time intervals, no significant differences were observed between the 3, 6, and 12 month values. The success rates of the materials decreased over time. CONCLUSIONS: FC and ABS were found successful as pulp dressings in primary molars. ABS appears to be an alternative pulpotomy agent but periodical follow-ups must be considered to evaluate long term success rates.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Alaçam A, Odabaş ME, Tüzüner T, Sillelioğlu H, Baygin O. Clinical and radiographic outcomes of calcium hydroxide and formocresol pulpotomies performed by dental students. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009; 108:e127–133.
American Academy of Paediatric Dentistry. Guideline on pulp therapy for primary and immature permanent teeth. Reference Manual, revised 2009; 33:212–219.
Ansari G, Ranjpour M. Mineral trioxide aggregate and formocresol pulpotomy of primary teeth: 2-year follow-up. International Endodontic Journal 2010; 43:413–418.
Bilgili H, Kosar A, Kurt M et al. Haemostatic efficacy of Ankaferd Blood Stopper (r) in a swine bleeding model. Med Prin Pract 2009; 18:165–169.
Croll TP, Killian CM. Zinc oxide-eugenol pulpotomy and stainless steel crown restoration of a primary molar. Quintessence Int 1992; 23:383–388.
Erdem AP, Guven Y, Balli B et al. Success rates of mineral trioxide aggregate, ferric sulphate, and formocresol pulpotomies: a 24-month study. Pediatr Dent 2011; 33:546–551.
Firat HC, Ozdemir O, Kosar A, Goker H, Haznedaroglu IC: Annual review of Ankaferd 08–09. Naviga publications, Istanbul, 2009, pp.13–19.
Fuks AB, Holan G, Davis JM, Eidelman E. Ferric sulphate versus dilute formocresol in pulpotomized primary molars: Long-term follow up. Pediatr Dent 1997; 19:327–330.
Fuks AB, Papagiannoulis L. Pulpotomy in primary teeth: Review of the literature according to standardized assessment criteria. Eur Arch Paediatr Dent 2006; 7:64–71.
Fuks AB. Vital pulp therapy with new materials for primary teeth: New directions and treatment perspectives. J. Endod 2008; 34(7S):S18–24.
Goker H, Haznedaroglu IC, Ercetin S et al. Haemostatic actions of the folkloric medicinal plant extract Ankaferd Blood Stopper®. J Int Med Res 2008; 36:163–170.
Holan G, Eidelman E, Fuks AB. Long-term evaluation of pulpotomy in primary molars using mineral trioxide aggregate or formocresol. Pediatr Dent 2005; 27:129–136.
Jabbarifar SE, Khademi AA, Gahsemi D. Success rate of formocresol pulpotomy versus mineral trioxide aggregate in human primary molar tooth. J Res Med Sci 2004; 6:304–307.
Kilpatrick NM, Neumann A. Durability of amalgam in the restoration of class II cavities in primary molars: a systematic review of the literature. Eur Arch Paediatr Dent 2007; 8:5–13.
Lee SJ, Umano K, Shibamoto T, Lee KG. Identification of volatile components in basil (Ocimum basilicum L.) and thyme leaves (Thymus vulgaris L.) and their antioxidant properties. Food Chem 2007; 91:131–137.
Lemon RR, Steele PJ, Jeansonne BG. Ferric sulphate haemostasis: Effect on osseous wound healing left in situ for maximum exposure. J Endod 1993; 19:170–173.
Matsuda H, Ando S, Kato T, Morikawa T, Yoshikawa M. Inhibitors from the rhizomes of Alpinia officinarum on production of nitric oxide in lipopolysaccharide-activated macrophages and the structural requirements of diarylheptanoids for the activity. Bioorg Med Chem 2006; 14:138–142.
Milnes AR. Persuasive evidence that formocresol use in pediatric dentistry is safe. J Can Den Assoc 2006; 72:247–248.
Moretti AB, Sakai VT, Oliveira TM et al. The effectiveness of mineral trioxide aggregate, calcium hydroxide, and formocresol for pulpotomies in primary teeth. Int Endod J 2008; 41:547–555.
Ng FK, Messer LB. Mineral trioxide aggregate as a pulpotomy medicament: A narrative review. Eur Arch Paediatr Dent 2008; 9:4–11.
Ni Chaollai A, Monteiro J, Duggal MS. The teaching of management of the pulp in primary molars in Europe: a preliminary investigation in Ireland and the UK. Eur Arch Paediatr Dent 2009; 10:98–103.
Odabaş ME, Cinar C, Tulunoglu O, Isik B. A new haemostatic agent’s effect on the success of calciumhydroxide pulpotomy in primary molars. Pediatric Dentistry 2011a; 33:546–551.
Odabaş ME, Erturk M, Cinar C, Tuzuner T, Tulunoğlu O. Cytotoxicity of a new haemostatic agent on human pulp fibroblasts in vitro. Med Oral Patol Oral Cir Bucal 2011b; 16:e584–587.
Olivi G, Genovese MD. Laser reflcetive dentistry in children and adolescents. Eur Arch Paediatr Dent 2011; 12:68–78.
Papagiannoulis L. Clinical studies on ferric sulphate as a pulpotomy medicament in primary teeth. Eur J Paediatr Dent 2002; 3:126–132.
Peng L, Ye L, Tan H, Zhou X. Evaluation of the formocresol vs mineral trioxide aggreagate primary molar pulpotomy: a meta-analysis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006; 102:e40–44.
Peng L, Ye L, Guo X et al. Evaluation of formocresol versus ferric sulphate primary molar pulpotomy: a systematic review and meta-analysis. In Endod J 2007; 40:751–757.
Rodd HD, Boissonade FM. Immunocytochemical investigation of immune cells within human primary and permanent tooth pulp. Int J Paediatr Dent 2006; 16:2–9.
Rodd HD, Waterhouse PJ, Fuks AB, Fayle SA, Moffat MA. Pulp therapy for primary molars. UK National Clinical Guidelines in Paediatric Dentistry. Int J Paediatr Dent. 2006; 16:15–23.
Sonmez D, Sari S, Cetinbas T. A comparison of four pulpotomy techniques in primary molars: A long-term follow-up. J Endod 2008; 34:950–955
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Yaman, E., Görken, F., Pinar Erdem, A. et al. Effects of folk medicinal plant extract Ankaferd Blood stopper® in vital primary molar pulpotomy. Eur Arch Paediatr Dent 13, 197–202 (2012). https://doi.org/10.1007/BF03262870
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF03262870