Abstract
AIM: To study the saliva profiles in children with severe heart disease taking heart failure medication compared with the saliva from healthy age and gender matched controls. STUDY DESIGN: Cross sectional case-control design. METHODS: Twenty-four age and gender matched pairs of children, mean age 12.0 years participated. Stimulated saliva was collected in a standardized way before lunchtime and the subjects were asked to refrain from all eating, drinking and tooth brushing 90 mins before sampling. Stimulated salivary secretion rate, buffering capacity, total salivary viable count of bacteria, mutans streptococci and lactobacilli, calcium, chloride, magnesium, potassium, sodium and salivary IgA were determined. RESULTS: There were 7 of the 24 children in the cardiac group who had secretions below 0.5 ml/min compared with no child in the control group (p<0.01). Lower than 106 total viable counts of bacteria (TVC) were detected in the cardiac group 1.4×106 ± 1.2×107 vs. 2.7×106 ± 2.9×107 in the control group (p<0.05). Mutans streptococci (MS) in the cardiac group were 5.2×104 ± 1.5×105 vs. 8.1 ×103 ± 1.3×104 in the control group, (p>0.05) and MS ratio of TVC constituted 0.11±0.35 per cent compared to 0.01±0.02 per cent for the control group (p>0.05). STATISTICS: Continuous data were analysed by an analysis of variance (ANOVA) and categorical data by chi-square test. CONCLUSION: Reduced salivary secretion could be a caries risk factor in children taking heart failure medication.
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Rosén, L., Rydberg, A., Sjöström, I. et al. Saliva profiles in children using heart failure medication: a pilot study. Eur Arch Paediatr Dent 11, 187–191 (2010). https://doi.org/10.1007/BF03262742
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DOI: https://doi.org/10.1007/BF03262742