Debridement could be a solution to promote healing of established oral mucositis in children
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Aim: The aim of the study was to present a novel approach to promote healing of established oral mucositis and to alleviate symptom clusters in a group of children who were on induction chemotherapy. Study Design: A clinical prospective study. Methods: Children (40) diagnosed with Grade 3 or 4 oral mucositis were randomly assigned into two groups: In Group I (n=20), accumulated debris on ulcerations was removed (debridement); In Group II (n=20), subjects had no debridement. The condition of oral lesions, speech, lips, teeth, saliva, gingiva, and swallowing ability were examined 3 x week during the study. All subjects received the same oral care regimen. They were well balanced in respect of age, the type of antineoplastic treatment, and the number. Results: Debridement promoted resolution and decreased the severity of oral mucositis significantly. Thus, the subjects had less oral discomfort, pain, and nutritional difficulties. Statistics: The data were entered in the SPSS 13.0 program, and the tests used were Kolmogorov-Smirnov, Shapiro-Wilk, Mann-Whitney, and Spearman’s correlation coefficient with a 5% significance level. Conclusion: Well-controlled, prospective clinical studies related to the management of established oral mucositis will lead to the development of potential interventions and improved patient care.
Key wordsOral mucositis debridement/resolution children
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- Armitage R Berry G. Inferences from proportions. In: Armitage P, Berry G, eds. Statistical Methods in Medical Research. Oxford, UK: Blackwell Scientific 1994; 118–132.Google Scholar
- Brown CG, Yoder LH. Stomatitis: an overview. Oncol Nurs Update 2002; 4:20–23.Google Scholar
- Dodd MJ, Larson PJ, Dibble SL, et al. Randomized clinical trial of chlorhexidine versus placebo for prevention of oral mucositis in patients receiving chemotherapy. Oncol Nurs Forum 1996; 6:921–927.Google Scholar
- Epstein JB, Schubert MM. Oral mucositis in myelosuppresive cancer therapy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1999; 3:273–276.Google Scholar
- Epstein JB, Schubert MM. Oropharyngeal mucositis in cancer therapy. Review of pathogenesis, diagnosis, and management. Oncology (Huntingt) 2003; 12:1767–1779.Google Scholar
- Madeya ML. Oral complications from cancer therapy: Part 1-Pathophysiology and secondary complications. Oncol Nurs Forum 1996; 5:801–807.Google Scholar
- Saadeh CE. Chemotherapy- and radiotherapy-induced oral mucositis: review of preventive strategies and treatment. Pharmacotherapy 2005; 4:54–55.Google Scholar
- Scully C, MacFarlane TW. Orafacial manifestations of childhood malignancy: clinical and microbiological findings during remission. J Dent Child 1983; 59:121–125.Google Scholar
- Wilkes JD. Prevention and treatment of oral mucositis following cancer chemotherapy. Semin Oncol 1998; 5:538–551.Google Scholar