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Adverse Effects of Amiodarone

Pathogenesis, Incidence and Management

  • Review Article
  • Adverse Drug Experience Review
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Summary

Amiodarone is an extremely effective antiarrhythmic agent for the treatment of both life-threatening ventricular arrhythmias and refractory supraventricular tachyarrhythmias. Subjective minor side effects are common with amiodarone but rarely require discontinuation of therapy and are often handled by dose reduction. Serious end-organ toxicity, including pulmonry fibrosis and drug-induced hepatitis, have been the most common indications for discontinuing amiodarone therapy in these patients.

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Authors and Affiliations

  1. Electrophysiology Laboratory, Division of Cardiology, University of Texas Medical School at Houston, P.O. Box 20708, Houston, Texas, 77225, USA

    Gerald V. Naccarelli, Robert L. Rinkenberger, Anne H. Dougherty & David M. Fitzgerald

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  1. Gerald V. Naccarelli
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  2. Robert L. Rinkenberger
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  3. Anne H. Dougherty
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  4. David M. Fitzgerald
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Naccarelli, G.V., Rinkenberger, R.L., Dougherty, A.H. et al. Adverse Effects of Amiodarone. Med Toxicol Adverse Drug Exp 4, 246–253 (1989). https://doi.org/10.1007/BF03259911

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