Comparative In Vitro Evaluation of Cefepime, an Aminothiazolyl Methoxyamino Cephem
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The in vitro activity of cefepime, a new aminothiazolyl methoxyamino cephem, was compared with other commonly used antimicrobial agents against 425 strains of Enterobacteriaceae, 138 isolates of other Gram-negative bacilli and 334 strains of Gram-positive cocci. The minimum inhibitory concentrations (MICs) of cefepime were between < 0.03 and 0.5 mg/L for 90% of the Enterobacteriaceae isolates tested, and all 60 isolates of Enterobacter cloacae and Serratia marcescens were inhibited by < 0.03 to 4.0 mg/L of this cephem. Cefepime was the most effective of the drugs tested against Aeromonas hydrophila; its activity against Pseudomonas aeruginosa, Xanthomonas maltophilia and Acinetobacter was comparable to that of ceftazidime and ceftriaxone. All the isolates of methicillin-susceptible Staphylococcus aureus were inhibited by a concentration of cefepime 0.5 to 8.0 mg/L. Cefepime inhibited all 176 isolates of Streptococcus pyogenes, S. agalactiae and S. pneumoniae at concentrations of < 0.015 to 1.0 mg/L. Like other members of its class, it had little or no activity against Xanthomonas, methicillin-resistant S. aureus and enterococci.
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