Summary
In a double-blind randomised parallel group trial a new angiotensin-converting enzyme (ACE) inhibitor, Spirapril, was compared to nitrendipine in 266 patients with hypertension (diastolic blood pressure 95 to 119mm Hg). Blood pressure was measured 24 hours after administration, and dose titration was performed every fourth week to achieve a diastolic blood pressure ⩽ 90mm Hg. After 4 weeks’ monotherapy with either nitrendipine 20mg once daily or Spirapril 12mg once daily, the dose was increased to 40mg once daily and 24mg once daily, respectively, if goal blood pressure had not been achieved. After 8 weeks of monotherapy hydrochlorothiazide 12.5mg once daily could be added.
Both treatments had a low response rate and the reduction in blood pressure was lower than expected. No significant difference was found in the reductions in blood pressures between the 2 treatment regimens. The effect of adding hydrochlorothiazide to Spirapril was as expected, while the combination with nitrendipine only had a marginal extra effect on blood pressure. Significantly more patients in the nitrendipine group were withdrawn due to adverse events (27%) than in the Spirapril group (7%).
In conclusion, at the dosages used, nitrendipine and Spirapril lower blood pressure to the same degree, but nitrendipine produces more adverse events. The addition of hydrochlorothiazide to nitrendipine cannot be recommended.
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References
Benjamin N, Phillips RJW, Robinson BF. Verapamil and bendrofluazide in the treatment of hypertension: a controlled study of effectiveness alone and in combination. European Journal of Clinical Pharmacology 34: 249–253, 1988
Brunner HR, Waeber B, Nussberger J, Schaller M-D. Long-term clinical experiences with enalapril in essential hypertension. Journal of Hypertension 1 (Suppl. 1): 103–107, 1983
Carlsen JE, Køber L. Blood pressure lowering effect and adverse events during treatment of arterial hypertension with isradipine and hydrochlorothiazide. Drug Investigation 2: 10–16, 1990
Carlsen JE, Køber L, Torp-Pedersen C, Johansen P. Relation between dose of bendrofluazide, antihypertensive effect and adverse biochemical effects. British Medical Journal 300: 975–978, 1990
Cirillo VJ, Gomez HJ, Salonen J, Salonen R, Rissanen V, et al. Lisinopril: dose-peak effect relationship in essential hypertension. British Journal of Clinical Pharmacology 25: 533–538, 1988
Editorial. Investigators brochure: TI 211/950/spirapril. Sandoz Ltd, Basel, 1988
Goa KL, Sorkin EM. Nitrendipine: an updated review. Drugs 33: 123–155, 1987
Hampton JR. Evidence suggesting that mild hypertension need not be treated. Journal of Hypertension 4 (Suppl. 5): s528–s532, 1986
Joint National Committee. The report of the Joint National Committee on detection, evaluation and treatment of high blood pressure. Archives of Internal Medicine 148: 1023–1038, 1988
Jürgensen HJ. Comparative effects of pinacidil and nifedipine in the treatment of arterial hypertension. Drugs 36 (Suppl. 7): 67–69, 1988
Medical Research Council Working Party. MRC trial of treatment of mild hypertension: principle results. British Medical Journal 291; 97–104, 1985
Rüdel H, Schmieder R, Langewitz W, Neus J, Wagner O, et al. Efficacy of nitrendipine as baseline antihypertensive therapy. Journal of Cardiovascular Pharmacology 6: s1049–s1052, 1984
Sánchez RA, Traballi CA, Barclay CA, Gilbert HB, Muscará M, et al. Antihypertensive, enzymatic, and hormonal activity of cilazepril, a new angiotensin-converting enzyme inhibitor in patients with mild to moderate essential hypertension. Journal of Cardiovascular Pharmacology 11: 230–234, 1988
Stoepel K, Deck K, Corsing C, Ingram C, Vanov SK. Safety aspects of long-term nitrendipine therapy. Journal of Cardiovascular Pharmacology 6: s1063–s1066, 1984
Webster J, Petrie JC, Robb OJ, Trafford J, Burgess J, et al. Enalapril in moderate to severe hypertension: a comparison with atenolol. British Journal of Clinical Pharmacology 21: 489–495, 1986
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Carlsen, J.E., Galløe, A., Køber, L. et al. Comparison of Efficacy and Tolerability of Spirapril and Nitrendipine in Arterial Hypertension. Drug Invest. 3, 172–177 (1991). https://doi.org/10.1007/BF03259560
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DOI: https://doi.org/10.1007/BF03259560