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Reversal of Tumour Drug Resistance with Monoclonal Antibodies

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Summary

Emergence of drug resistance is a major problem in cancer chemotherapy. P-glycoprotein, a product of the MDR1 gene, plays an important role in multidrug resistance. Since P-glycoprotein is expressed on the tumour cell surface, therapeutic application of monoclonal antibodies (mAbs) against P-glycoprotein has been considered. Anti-P-glycoprotein mAbs enhance immune responses against multidrug-resistant tumours expressing P-glycoprotein, and also inhibit the transport function of P-glycoprotein. Accordingly, selective elimination of multidrug-resistant tumours has been demonstrated in vitro and in vivo. Although there remain many questions to be solved, selective targeting of multidrug-resistant tumours by anti-P-glycoprotein mAbs is a promising strategy for overcoming multidrug resistance.

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Authors and Affiliations

  1. Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, 113, Japan

    Mikihiko Naito & Takashi Tsuruo

  2. Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan

    Takashi Tsuruo

Authors
  1. Mikihiko Naito
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  2. Takashi Tsuruo
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Naito, M., Tsuruo, T. Reversal of Tumour Drug Resistance with Monoclonal Antibodies. Clin. Immunother. 5, 91–95 (1996). https://doi.org/10.1007/BF03259316

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