Stem Cell Factor
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Stem cell factor (SCF) is the ligand for the proto-oncogene c-kit. As a single agent it has only weak stimulatory effects on haemopoietic cells. However, when administered in combination with other haemopoietic growth factors it has the ability to stimulate the proliferation of committed as well as primitive haemopoietic cells.
A phase I/II study has explored the ability of SCF plus granulocyte colony-stimulating factor (G-CSF) to mobilise peripheral blood progenitor cells for reinfusion after high dosage chemotherapy. The combination of SCF plus G-CSF resulted in a 2-fold greater increase in the peripheral white blood cell count compared with G-CSF alone, as well as increases in granulocyte-macrophage colony-forming cells and CD34+ cells. There was a trend to accelerated platelet recovery following reinfusion of cells mobilised with SCF plus G-CSF compared with G-CSF alone.
Additional studies are required to define further the roles of SCF in the mobilisation of peripheral blood progenitor cells and in other potential therapeutic areas, such as treatment of bone marrow failure or HIV infection.
KeywordsStem Cell Factor Bone Marrow Failure Peripheral Blood CD34 Peripheral Blood Progenitor Cell Haemopoietic Cell
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