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Clinical Immunotherapeutics

, Volume 1, Issue 4, pp 307–318 | Cite as

Antiadhesion Peptides in the Prevention of Tumour Metastasis

  • Ikuo Saiki
Review Article Disease Treatment Review

Summary

The adhesive interaction between tumour cells and host cells or the extracellular matrix plays a crucial role in metastasis formation. We have used synthetic or recombinant polypeptide analogues, such as poly(RGD), based on the Arg-Gly-Asp (RGD) sequence found in fibronectin, or CH-271, based on functional domains in fibronectin, to regulate the mechanisms involved in cell adhesion during the metastatic process. Poly(RGD) inhibited experimental lung and liver metastasis effectively when coinjected intravenously with various types of tumours. In a model of spontaneous lung metastasis using the B16-BL6 melanoma, repeated administration of this polypeptide before or after surgical excision of the primary tumour resulted in a significant inhibition of tumour metastasis without affecting the growth of the primary tumour, and substantially prolonged the survival time of mice. The mechanism responsible for the inhibition of tumour metastasis by the polypeptides is at least partly associated with the ability to interfere with cellular functions such as adhesiveness, motility and invasiveness in the process of metastasis. Coadministration of the CH-271 fusion polypeptide and anticancer drugs, i.e. antiadhesion therapy combined with chemotherapy, caused a dramatic inhibition of lung and liver metastasis of tumours as compared with either treatment alone or with the control. Since the polypeptides derived from cell adhesion molecules show no short term toxicity to the host, they may provide a new and promising approach for the control and prevention of cancer metastasis.

Keywords

Adis International Limited Laminin Tumour Metastasis Metastatic Melanoma Cell Inhibit Tumour Metastasis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Adis International Limited 1994

Authors and Affiliations

  • Ikuo Saiki
    • 1
  1. 1.Research Institute for Traditional Sino-Japanese MedicinesToyama Medical and Pharmaceutical UniversityToyamaJapan

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