Summary
In a prospective randomised multicentre study, the effects of cefazolin sodium and ceftizoxime on the prevention of postoperative infection were investigated in 117 patients undergoing abdominal surgery. Each drug was administered intravenously twice daily (cefazolin 4 g/day or ceftizoxime 2 g/day) for 5 days postoperatively. No statistically significant difference was noted in the incidence of infection between the 2 treated groups (cefazolin 11.5% and ceftizoxime 8.9%), and there were no serious adverse events in either group. The fever index was significantly higher in patients with postoperative infections when compared with noninfected individuals in both treatment groups, but showed no correlation with age, time of surgery or blood loss. In terms of cost, prophylactic treatment with cefazolin is recommended for such patients with a low level of anaerobic contamination.
Similar content being viewed by others
References
Burke JF. The effective period of preventive antibiotic action in experimental incisions and dermal lesions. Surgery 50: 161–168, 1961
Cruse PJE, Foord R. A five-year prospective study of 23,649 surgical wounds. Archives of Surgery 107: 206–210, 1973
Hall JC, Hall JL, Christiansen K. A comparison of the roles of cefamandole and ceftriaxone in abdominal surgery. Archives of Surgery 126: 512–516, 1991
Kaiser AB. Antimicrobial prophylaxis in surgery. New England Journal of Medicine 315: 1129–1138, 1986
Kaiser AB, Petracek MR, Lea JW IV, et al. Efficacy of cefazolin, cefamandole, and gentamicin as prophylactic agents in cardiac surgery. Annals of Surgery 206: 791–797, 1987
Kernodle DS, Classen DC, Burke JP, Kaiser AB. Failure of cephalosporins to prevent Staphylococcus aureus surgical wound infections. Journal of the American Medical Association 263: 961–966, 1990
National Research Council, Ad Hoc Committee on trauma, Division of Medical Sciences. Organization, methods and physical factors. Annals of Surgery 160 (Suppl.): 19–31, 1964
Regamy C, Libke RD, Engelking ER, Clarke JT, Kirby WMM. Inactivation of cefazolin, cefaloridine, and cephalothin by methicillin-sensitive and methicillin-resistant strains of Staphylococcus aureus. Journal of Infectious Diseases 13: 291–294, 1975
Rotman N, Hay JM, Lacaine F. Prophylactic antibiotherapy in abdominal surgery. Archives of Surgery 124: 323–327, 1989
Sakai K, Kinoshita H, Fujimoto M, Ueda T. Studies on the evaluation of the efficacy of prophylactic antibiotics in postoperative surgical infections. Chemotherapy 33: 1086–1094, 1985
Slama TG, Sklar SJ, Misinski J, Fess SW. Randomized comparison of cefamandole, cefazolin, cefuroxime prophylaxis in open heart surgery. Antimicrobial Agents and Chemotherapy 29: 744–747, 1986
Stone HH, Haney BB, Kolb LD, et al. Prophylactic and preventive antibiotic therapy: timing, duration and economics. Annals of Surgery 189: 691–699, 1979
Author information
Authors and Affiliations
Consortia
Additional information
Members of the Cooperative Study Group are listed on page 68.
An erratum to this article is available at http://dx.doi.org/10.1007/BF03259585.
Rights and permissions
About this article
Cite this article
Hashizume, M., Sugimachi, K. & The Cooperative Study Group. A Comparative Study of Ceftizoxime and Cefazolin Prophylaxis in Upper Digestive Tract and Biliary Surgery. Drug Invest 5, 63–68 (1993). https://doi.org/10.1007/BF03259229
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF03259229