Drug Investigation

, Volume 4, Issue 6, pp 501–507 | Cite as

Efficacy of Pirlindole, a Highly Selective Reversible Inhibitor of Monoamine Oxidase Type A, in the Prevention of Experimentally Induced Epileptic Seizures

  • A. Medvedev
  • V. Gorkin
  • V. Shvedov
  • O. Fedotova
  • I. Fedotova
  • A. Semiokhina
Original Research Article


Intraperitoneal administration of pirlindole (pirazidole) or ‘soluble pirlindole’ 50 mg/kg body-weight prolonged the onset of seizures and decreased the intensity of seizures in rats genetically selected for high sensitivity to audiogenic hereditary epilepsy [Krushinsky-Molodkina (KM) rats]. In this experimental model of epilepsy, pirlindole prevented qualitative alteration (transformation) in the catalytic activity of membrane-bound type A monoamine oxidases (MAO-A), pathogenetically important for the development of the audiogenic seizures. Modification of the enzymatic properties of the monoamine oxidases causes an increase in γ-aminobutyric acid (GABA) deamination in the mitochondrial fraction of the brain. The data obtained suggest that selective inhibitors of MAO-A, such as pirlindole, may prevent experimental epileptic seizures.


Monoamine Oxidase Drug Invest Amine Oxidase Clorgyline Audiogenic Seizure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Adis International Limited 1992

Authors and Affiliations

  • A. Medvedev
    • 1
  • V. Gorkin
    • 1
  • V. Shvedov
    • 2
  • O. Fedotova
    • 2
  • I. Fedotova
    • 3
  • A. Semiokhina
    • 3
  1. 1.Institute of Biological and Medical ChemistryAcademy of Medical SciencesMoscowRussia
  2. 2.Centre of Drug Chemistry - the All-Union Institute of Pharmaceutical ChemistryMoscowRussia
  3. 3.Biological FacultyMV Lomonosov State UniversityMoscowRussia

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