Comparative Double-Blind Multicentre Study of Single-Dose Pefloxacin and Amoxicillin Plus Probenecid for Treatment of Acute Uncomplicated Gonorrhoea
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In a double-blind, randomised multicentre study, 129 patients (92 males, 37 females) with culture proven acute uncomplicated genital gonorrhoea were given single oral doses of either Pefloxacin 800mg (n = 65) or amoxicillin 3.0g plus probenecid 1.0g (n = 64). Data from 36 patients (19 Pefloxacin and 17 amoxicillin plus probenecid) were not évaluable. All 146 strains of Neisseria gonorrhoeae isolated from evaluable patients were sensitive to Pefloxacin whereas 139 of 146 were sensitive to penicillin (statistically significant at p < 0.05, binomial test).
84% of gonococcal infections involved only a genital site whereas implication of other sites was observed in 11% of patients; 4% of the patients were asymptomatic carriers of infected participants. Cure (negative post-treatment culture) rates were 100% (65/65) in pefloxacin-treated patients and 94% (60/64) in the amoxicillin plus probenecid group: the 4 treatment failures were 3 men with positive N. gonorrhoeae urethral cultures and a woman with a positive throat culture. Postgonococcal urethritis was observed in 9 pefloxacin and 4 amoxicillin plus probenecid-treated patients. 18% of pefloxacin-treated patients and 15% of amoxicillin plus probenecid-treated patients presented drug-related adverse events consisting mainly of gastrointestinal (nausea, diarrhoea) or CNS (headache) disturbances of mild intensity. Two amoxicillin plus probenecid patients presented post-treatment Candida albicans vaginitis requiring antifungal therapy. In conclusion, results from this study indicate that a single oral 800mg dose of Pefloxacin can be considered as well tolerated and as effective as the amoxicillin plus probenecid combination for the treatment of acute uncomplicated gonorrhoea.
KeywordsAmoxicillin Probenecid Chlamydia Trachomatis Pefloxacin Neisseria Gonorrhoeae
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- Barry AL, Thronsberry C. Susceptibility tests; diffusion test procedures. In Lennette et al. (Eds) Manual of clinical microbiology, 4th ed., pp. 978–987, American Society for Microbiology, Washington, DC, 1985Google Scholar
- Editorial. Treatment of sexually transmitted diseases. Medical Letter on Drugs and Therapeutics 28: 23–28, 1986Google Scholar
- Editorial. Treatment of sexually transmitted diseases. Medical Letter on Drugs and Therapeutics 32: 5–10, 1990Google Scholar
- Garrell JB, Thabaut A, Grossetête G, Forestier JF, Normand P. Efficacy and safety of Pefloxacin in male gonococcal urethritis. Abstract P54.6/4-10. 13th International Congress of Chemotherapy, Vienna, August 28 to September 2, 1983Google Scholar
- Schacter J. Chlamydiae (Psittacosis — lymphogranuloma venereum — trachoma group). In Lennette et al. (Eds) Manual of clinical microbiology, 4th ed., pp. 856–862, American Society for Microbiology, Washington, DC, 1985Google Scholar
- Schoenknecht FD, Sabath LD, Thornsberry C. Susceptibility tests: special tests. In Lennette et al. (Eds) Manual of clinical microbiology, 4th ed., pp. 1000–1008, American Society for Microbiology, Washington, DC, 1985Google Scholar