Clinical Immunotherapeutics

, Volume 2, Issue 6, pp 430–442 | Cite as

Immunopathogenesis and Management of Myasthenia Gravis

  • Aashit K. Shah
Practical Therapeutics


Myasthenia gravis is a well known and well understood autoimmune disorder. Weakness in patients with myasthenia gravis is caused by the autoimmune destruction of acetylcholine receptors at the neuromuscular junction. The autoimmune mechanisms are not simple, and involve T cells, B cells and their interactions.

Tools for the diagnosis of myasthenia gravis include: (a) clinical evaluation; (b) determination of the serum anti-acetylcholine receptor antibody; and (c) electro-diagnostic methods such as single fibre electromyography and repetitive nerve stimulation. Treatment involves symptomatic treatment with acetylcholinesterase inhibitors and both conventional (corticosteroids and other immunosuppressants) and nonconventional (plasmapheresis, intravenous immunoglobulin and thymectomy) immunomodulating therapies.


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Copyright information

© Adis International Limited 1994

Authors and Affiliations

  • Aashit K. Shah
    • 1
  1. 1.Department of NeurologyWayne State University, 6E University Health CenterDetroitUSA

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